Search research articles

关于 JoVE

概览领导团队博客 JoVE 帮助中心

作者

出版流程编辑委员会范围与政策同行评审常见问题投稿

图书馆员

用户评价订阅访问资源图书馆顾问委员会常见问题

研究

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments 存档

教育

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual 教师资源中心教师网站

使用条款与条件

相关概念视频

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序

Same author

Alveolar Bone Regeneration: Smart Biomaterials and Physical Stimulation.

Journal of biomedical materials research. Part B, Applied biomaterials·2026

Same author

PRMT5 inhibition impairs Fanconi Anemia pathway-mediated homologous recombination and enhances the antitumor efficacy of Temozolomide in glioblastoma.

Cell death & disease·2026

Same author

Growth Factor-Free Engineered Biphasic Scaffold for Enhanced Bone Regeneration.

Annals of biomedical engineering·2025

Same author

Facial nerve pathology: emerging strategies for regeneration and functional restoration.

Journal of materials chemistry. B·2025

Same author

Advancements in stimulation therapies for peripheral nerve regeneration.

Biomedical materials (Bristol, England)·2024

Same author

Hydrogel-Based Strategies for Intervertebral Disc Regeneration: Advances, Challenges and Clinical Prospects.

Gels (Basel, Switzerland)·2024

Same journal

FIBER DIAMETER-DRIVEN MODULATION OF CELL BEHAVIOR IN DECM-ENRICHED ELECTROSPUN SCAFFOLDS FOR BONE TISSUE ENGINEERING.

International journal of high speed electronics·2026

查看所有相关文章

Search research articles

相关实验视频

Updated: May 15, 2025

Electrospun Nanofiber Scaffolds with Gradations in Fiber Organization

Electrospun Nanofiber Scaffolds with Gradations in Fiber Organization

Published on: April 19, 2015

微纳米结构聚合物支架用于骨组织工程.

Sama Abdulmalik¹, Suranji Wijekoon¹, Khadija Basiru Danazumi^2,1

¹Department of Orthopedic Surgery, University of Connecticut Health Center, Farmington, CT 06030, USA.

International journal of high speed electronics

|April 8, 2025

概括

此摘要是机器生成的。

3D打印的PLLA原体支架通过模仿本地骨结构和促进细胞生长来增强骨再生. 这些生物活性植入物为传统骨移植提供了一个有希望的替代方案.

关键词:

骨组织工程骨组织工程原体I型纳米纤维人类介质细胞干细胞骨质性分化的骨质性差异化聚 (L-乳酸) 聚 (L-乳酸) 是一种

更多相关视频

Distinctive Capillary Action by Micro-channels in Bone-like Templates can Enhance Recruitment of Cells for Restoration of Large Bony Defect

Distinctive Capillary Action by Micro-channels in Bone-like Templates can Enhance Recruitment of Cells for Restoration of Large Bony Defect

Published on: September 11, 2015

A Facile and Eco-friendly Route to Fabricate PolyLactic Acid Scaffolds with Graded Pore Size

A Facile and Eco-friendly Route to Fabricate PolyLactic Acid Scaffolds with Graded Pore Size

Published on: October 17, 2016

相关实验视频

Last Updated: May 15, 2025

Electrospun Nanofiber Scaffolds with Gradations in Fiber Organization

Electrospun Nanofiber Scaffolds with Gradations in Fiber Organization

Published on: April 19, 2015

Distinctive Capillary Action by Micro-channels in Bone-like Templates can Enhance Recruitment of Cells for Restoration of Large Bony Defect

Distinctive Capillary Action by Micro-channels in Bone-like Templates can Enhance Recruitment of Cells for Restoration of Large Bony Defect

Published on: September 11, 2015

A Facile and Eco-friendly Route to Fabricate PolyLactic Acid Scaffolds with Graded Pore Size

A Facile and Eco-friendly Route to Fabricate PolyLactic Acid Scaffolds with Graded Pore Size

Published on: October 17, 2016

科学领域:

生物材料科学生物材料科学
组织工程是组织工程.
再生医学是一种再生医学.

背景情况:

传统的骨移植 (异构移植,自体移植) 面临着可用性和免疫排斥等局限性.
组织工程植入物为骨修复和再生提供了一个有希望的替代方案.
3D打印技术的进步使得复杂的功能性脚手架能够被制造出来.

研究的目的:

设计和制造具有机械能力的3D打印聚 (L-乳酸) (PLLA) 脚手架.
为了增强PLLA支架与原I型纳米纤维的生物活性.
为了评估微纳米结构的PLLA和PLLA-原支架与骨髓 stromal 细胞 (BMSCs) 进行骨再生的性能.

主要方法:

制造3D打印的PLLA微结构脚手架.
结合I型原蛋白纳米纤维来创建PLLA-原体支架.
在体外和体外评估BMSC的支架性能,评估细胞粘附,增殖,骨质分化和骨形成.

主要成果:

PLLA-原支架成功地模仿了状骨架构和机械性能.
这两种支架类型都支持BMSC粘附,增殖和骨质分化.
与PLLA支架相比,PLLA-原支架表现出优越的宿主细胞分布,骨密度和矿化.
原蛋白纳米结构显著诱导骨质转录并引导成熟骨基质的形成.

结论:

微纳米结构的PLLA原体支架有效地重建了原生骨细胞外基质的诱导微环境.
这些支架触发了功能性骨再生所必需的细胞事件.
开发的脚手架作为一个可行的替代材料平台来修复关键大小的骨缺陷.