最近在使用草药和合成药物控制登革热方面取得了进展
Sayyed Jafar Hasani1, Giovanni Sgroi2, Bijan Esmaeilnejad3
1Neurophysiology Research Center, Cellular and Molecular Medicine Research Institute, Urmia University of Medical Sciences, Urmia, Iran.
Heliyon
|April 8, 2025
概括
登革热病毒 (DENV) 是一个日益严重的全球健康问题. 本综述探讨了用于DENV预防和治疗的有希望的合成和天然化合物,强调了需要有效的疗法和疫苗的需要.
科学领域:
- 病毒学 病毒学
- 公共卫生 公共卫生
- 药理学 药理学是指药理学的学科.
背景情况:
- 登革热病毒 (DENV) 构成了严重的全球健康威胁,其发病率和地理传播正在增加.
- DENV感染引起不同的临床表现,从轻度发烧到严重的出血性疾病和休克.
- 存在四种DENV血清型,所有这些都能够引起严重的疾病,使治疗和预防复杂化.
研究的目的:
- 审查登革热病毒 (DENV) 预防和治疗的创新方法.
- 检查针对DENV.的植物化学和合成治疗策略.
- 为了突出需要有效的DENV干预,由于目前的选择有限.
主要方法:
- 关于合成抗登革热化合物 (例如,JNJ-1802,纳夫托基诺,利格南) 的科学文献的综述.
- 研究来自药用植物的天然化合物 (例如, *Hippophae rhamnoides*, *Azadirachta indica*, *Cymbopogon citratus*) 具有抗病毒性质.
- 分析当前的候选疫苗及其在临床试验中的有效性.
主要成果:
- 一些合成化合物和植物性天然产品显示出抑制DENV复制的潜力,在体外和体内.
- 目前,美国食品和药物管理局 (FDA) 尚未批准任何DENV特异性疗法.
- 现有的DENV疫苗的保护效果有限,这表明需要改进免疫策略.
结论:
- 对于具有低副作用的新型,有效的登革热病毒 (DENV) 疗法有着至关重要的需求.
- 合成药物开发和植物来源的探索都为DENV治疗提供了有前途的途径.
- 推进治疗干预和免疫策略对于打击全球登革热负担至关重要.
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