良性前列腺增生增加长期慢性病风险
Chenxi Ouyang1, Liang Zhou2, Jiahao Liu2
1Clinical Research Center The Third Xiangya Hospital of Central South University, Changsha, China; Department of Pharmacy, The Affiliated Nanhua Hospital, Hengyang Medical School University of South China, Hengyang, Hunan, China.
Mayo Clinic proceedings
|April 8, 2025
概括
患有良性前列腺增生症 (BPH) 的男性面临更高的慢性病 (CKD) 风险. BPH药物进一步增加了这种风险,强调了对这些患者功能监测的必要性.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學.
- 泌尿器科 泌尿器科 泌尿器科 泌尿器科
- 流行病学 流行病学
背景情况:
- 良性前列腺增生症 (BPH) 是老年男性常见的疾病.
- 慢性病 (CKD) 是一个重要的公共卫生问题.
- 包括药物效应在内的BPH和CKD之间的关系需要进一步研究.
研究的目的:
- 评估良性前列腺增生症 (BPH) 与慢性病 (CKD) 发生率之间的长期关联.
- 研究BPH药物对CKD和末期病 (ESKD) 风险的影响.
主要方法:
- 使用英国生物库数据 (2006-2010) 进行的前性队列研究.
- 包括198,399名没有基线CKD的男性参与者.
- 考克斯的比例危险模型分析了BPH,其药物治疗,以及CKD/ESKD发病率.
主要成果:
- 在中位数13.58年的随访后,BPH诊断与CKD风险增加有关 (HR,1.26;95% CI,1.10至1.45).
- 在BPH患者中,使用BPH药物显著增加了CKD风险 (HR,1.48;95% CI,1.18至1.85).
- 在BPH患者中观察到ESKD风险增加的趋势 (HR,1.49;95% CI,0.72到3.08).
结论:
- 患有BPH的患者长期患有CKD的风险更高.
- 在BPH患者中,BPH药物与CKD风险增加有关.
- 对被诊断患有BPH的男性来说,定期监测功能至关重要.
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