关于神经神经调节在慢性便秘中的有效性随机对照试验的元分析
Sameh Hany Emile1, Justin Dourado2, Anjelli Wignakumar2
1Ellen Leifer Shulman and Steven Shulman Digestive Disease Center, Cleveland Clinic Florida, Weston, FL, USA; Colorectal Surgery Unit, General Surgery Department, Mansoura University Hospitals, Mansoura, Egypt.
概括
圣神经调节 (SNM) 是慢性便秘的安全治疗方法,但与对照组相比,本次审查没有发现便秘或生活质量的显著改善.
科学领域:
- 胃肠病学 胃肠病学
- 神经学 神经学
- 手术创新 在外科创新.
背景情况:
- 慢性便秘显著影响患者的生活质量.
- 圣神经调节 (SNM) 是一种新兴的耐火性便秘治疗方案.
研究的目的:
- 系统地审查随机对照试验 (RCT),评估SNM治疗成年人慢性便秘的疗效.
- 评估便秘症状和生活质量 (QoL) 的改善作为主要结局.
- 评估与SNM相关的不良事件的发生率.
主要方法:
- 系统审查来自PubMed,Scopus和Web of Science的RCT,截至2024年3月.
- 包括5项与187名成年患者的RCT,将SNM与假刺激或保守治疗进行比较.
- 使用ROBIS和GRADE指南评估偏见风险和证据确定性.
主要成果:
- 在SNM和对照组之间,便秘缓解几率没有显著差异 (OR: 1.92,p=0.217).
- 在SNM (27.9%) 与对照 (18.4%) 的便秘得分中,中位数的降低略大,但在统计学上并不显著.
- 两组之间没有观察到生活质量或不良事件发生率的显著差异.
结论:
- 圣神经调节 (SNM) 显示在慢性便秘中具有有利的安全性.
- 目前的证据表明,SNM对便秘症状或生活质量没有显著的有形益处.
- 可能需要进一步的高质量研究来澄清SNM在治疗慢性便秘中的作用.
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