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暴露于尘埃的老鼠肠道微生物组和新陈代谢特征

Xi Shen¹, Miaomiao Wang¹, Shasha Pei¹

¹Hebei Province Key Laboratory of Occupational Health and Safety for Coal Industry, School of Public Health, North China University of Science and Technology, Tangshan, Hebei, 063210, P.R. China.

Combinatorial chemistry & high throughput screening

|April 8, 2025

概括

暴露于包括二氧化在内的尘埃会改变肠道细菌和大鼠的新陈代谢,为肺结核病提供潜在的早期诊断标志物. 这项研究强调了肠道菌群,代谢变化和肺部疾病发展之间的联系.

科学领域:

肺部医学肺部医学
微生物学微生物学
代谢学代谢学代谢学

背景情况:

病和肺病缺乏有效的治疗方法,需要对它们的病理生理学进行研究.
代谢学可以识别生物标志物,以了解疾病的发展.

研究的目的:

研究煤灰和暴露对大鼠肠道菌群和代谢概况的影响.
为了确定潜在的生物标志物用于早期诊断肺炎.

主要方法:

18只老鼠被分为对照组,煤尘组和二氧化组,暴露8周.
使用16S rDNA测序分析肠道菌群;通过UHPLC-QTOFMS分析便代谢物.
评估了肺部病理和炎症标志物 (IL-6,IL-11).

主要成果:

暴露减少了老鼠的体重,增加了IL-6/IL-11;观察到肺损伤和结节的形成.
暴露于尘埃改变了肠道微生物群的多样性 (α和β多样性).
确定了11种不同的便代谢物,表明代谢中断.

结论:

暴露于尘埃显著影响肠道菌群和宿主新陈代谢.
诸如果糖/甘和脂代谢等代谢途径都与此有关.
研究结果表明,这可能是用于早期肺结核病诊断的潜在生物标志物.

关键词:

肺炎结核病是一种肺结核病.炎症因素. 炎症因素.肠道菌群是指肠道上的植物.代谢生物组的代谢生物组潜在的生物标志物暴露于二氧化的情况.

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