血清sST2:COVID-19患者的关键生物标志物,对冠状动脉疾病有影响
Xueqin Li1, Yaxin Tian2,3, Hongyan Cao4
1Department of Laboratory Medicine, Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Third Hospital of Shanxi Medical University, Tongji Shanxi Hospital, Taiyuan, 030032, China.
2基因蛋白 (sST2) 的血清溶解生长刺激表达是COVID-19冠状动脉疾病 (CAD) 患者的独立风险因素. 较高的sST2水平与CAD严重程度相关,并预测不良结果,有助于风险分层.
科学领域:
- 心脏病学 心脏病学
- 传染性疾病 传染性疾病
- 生物标志物 生物标志物
背景情况:
- 后COVID-19综合征 (PS) 给健康带来了重大挑战,COVID-19患者患有冠状动脉疾病 (CAD) 面临着更高的并发症风险.
- 关于PS患者中CAD的患病率的数据有限,需要进一步调查.
研究的目的:
- 为了调查COVID-19,冠状动脉疾病 (CAD) 和COVID-19后综合征 (PS) 之间的关联.
- 确定预测CAD严重程度和COVID-19患者不良结果的生物标志物.
主要方法:
- 在2022年12月至2023年1月期间入院的75名COVID-19和68名非COVID-19患者的回顾性分析.
- 冠状动脉样硬化严重程度的评估使用Gensini分数 (GS).
- 收集人口统计,实验室和临床数据,包括2基因蛋白 (sST2) 的血清可溶性生长刺激表达.
主要成果:
- 患有CAD的COVID-19患者表现出较高的sST2,炎症标志物和心脏生物标志物水平,以及长时间住院和增加的发病率 (心力衰竭,急性冠状动脉综合征).
- 血清sST2被确定为COVID-19患者同时存在CAD (OR 1.122) 的独立风险因素.
- sST2水平与根西尼分数 (r=0.474,p<0.001) 呈正相关性,并预测ICU入院,住院时间和发病率与GS相似.
结论:
- 入院血清sST2水平对于COVID-19患者患有CAD类症状的治疗计划是有价值的.
- sST2作为COVID-19与CAD共存的预后生物标志物,有助于临床风险分层.
更多相关视频
08:48Dynamic Monitoring of Seroconversion using a Multianalyte Immunobead Assay for Covid-19
Published on: February 16, 2022
18:11A Research Method For Detecting Transient Myocardial Ischemia In Patients With Suspected Acute Coronary Syndrome Using Continuous ST-segment Analysis
Published on: December 28, 2012
相关概念视频
Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
Blood Studies for Cardiovascular System I: Cardiac Biomarkers
The essential diagnostic tools for detecting myocardial necrosis and monitoring individuals suspected of having acute coronary syndrome (ACS) include:
Troponins
Troponins, particularly cardiac troponins I and T, are the most precise and sensitive markers of myocardial injury. They are detectable within 4-6 hours of myocardial injury and remain...
Blood Studies for Cardiovascular System III: Serum Lipid Profile
Serum lipids are fats and fatty substances in the blood and are crucial for various bodily functions, including energy storage, cellular structure, and hormone production. Serum lipids consist of cholesterol, triglycerides, and phospholipids.
Cholesterol is a soft, fat-like substance found in all body cells. It is crucial for producing hormones, vitamin D, and substances that aid...
