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新型炎症标志物与过度活跃的膀之间的关联:NHANES 2009至2018年的横截面研究
Liangwei Wan1,2, Zhipeng Wang1,2, Lei Zhang1,2
1Department of Urology, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, China.
BMC urology
|April 8, 2025
概括
系统性炎症标志物,包括系统性免疫炎症指数 (SII),中性粒细胞与淋巴细胞比率 (NLR) 和系统性炎症反应指数 (SIRI),与过度活跃的膀 (OAB) 有关. 这些发现表明炎症可能有助于OAB的发展.
科学领域:
- 泌尿器科 泌尿器科 泌尿器科 泌尿器科
- 免疫学 免疫学 免疫学
- 公共卫生 公共卫生
背景情况:
- 过度活性膀 (OAB) 是一种影响许多个体的疾病,但其潜在的病理生理学尚未完全理解.
- 炎症过程越来越多地与各种慢性疾病有关.
研究的目的:
- 检查关键炎症标志物与过度活跃膀 (OAB) 的患病率之间的关联.
- 为了确定OAB风险分层的潜在炎症生物标志物.
主要方法:
- 利用了2009-2018年国家健康和营养检查调查 (NHANES) 的19,194名参与者的数据.
- 采用多变量逻辑回归和受限立方脊柱 (RCS) 分析来评估炎症标志物 (SII,NLR,PLR,SIRI) 和OAB (由OABSS定义) 之间的关系.
- 进行了子组分析,特别是检查了年龄的影响.
主要成果:
- 在OAB和系统性免疫炎症指数 (SII),中性粒细胞与淋巴细胞比率 (NLR) 和系统性炎症反应指数 (SIRI) 的较高四分位数之间发现了积极的相关性.
- 对于血小板与淋巴细胞比率 (PLR) 没有观察到显著的关联.
- 限制性立方线分析揭示了SII,NLR,SIRI和OAB之间的非线性关系,年龄被确定为一个重要因素.
结论:
- 升高的SII,NLR和SIRI与OAB的可能性增加有关,这表明系统性炎症在OAB的发病过程中可能发挥作用.
- 这些炎症标志物可以作为指标来识别具有较高OAB风险的个体.
- 需要进一步的前性研究来确认因果关系和临床效用.
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