在口服抗癌疗法中管理坚持,暴露和毒性
1Department of Pharmacy, The Cancer Institute Hospital of JFCR, 3-8-31 Ariake, Koto-Ku, Tokyo, 135-8550, Japan. kazuo.sugita@jfcr.or.jp.
Journal of pharmaceutical health care and sciences
|April 8, 2025
概括
优化口服抗癌剂 (OAA) 治疗需要药剂师专注于患者的坚持,降低暴露风险和管理副作用. 干预措施改善了瘤药房环境中的合规性,安全性和耐受性.
科学领域:
- 瘤学 药房 药房
- 药物治疗 药物治疗
- 患者安全 患者安全
背景情况:
- 口服抗癌剂 (OAAs) 的使用越来越多,需要强有力的管理策略.
- 关键的挑战包括患者的坚持,职业暴露风险和不良影响管理.
- 优化OAA治疗对于改善癌症护理患者的治疗结果至关重要.
研究的目的:
- 审查和突出重点战略,以加强对OAAs的遵守.
- 评估减少与OAA相关的职业暴露风险的方法.
- 检查有效的管理方法对OAA的不良影响.
主要方法:
- 在转移性结肠直肠癌 (mCRC) 患者中,评估了trifluridine/tipiracil化物 (TFTD) 的坚持率和影响因素.
- 评估泄漏套件的使用情况和安全培训对个人防护设备 (PPE) 合规性的影响.
- 检查了regorafenib诱导的不良反应,包括手脚皮肤反应 (HFSR) 和甲状腺功能低下症,以及它们的管理.
主要成果:
- 观察到85.0%的TFTD坚持率,恶心和疼痛影响了遵守;药剂师的干预改善了坚持.
- 在安全研讨会后,个人防护设备的合规性达到100%,强调需要持续培训和改进泄漏管理.
- 雷戈拉芬尼导致高HFSR (81.4%) 和甲状腺功能低下 (42.8%) 的高率;早期干预改善了耐受性,并确定了生存关联.
结论:
- 药剂师驱动的干预措施对于改善OAA遵守,确保职业安全和管理不良影响至关重要.
- 有效的管理策略,包括患者教育和支持性护理,提高治疗耐受性和患者的治疗结果.
- 持续的研究和合作对于优化瘤药房实践中的OAA治疗至关重要.
关键词:
坚持的坚持 坚持的坚持负面影响管理手脚皮肤反应手脚皮肤反应甲状腺功能低下症 甲状腺功能低下症药物的安全性 药物的安全性职业暴露 职业暴露瘤学药房 瘤学药房口服抗癌药物可以使用.患者教育 患者教育药剂师的干预是药剂师的干预更多相关视频
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