吸入式和鼻腔生物制剂:分析,配方,开发和监管方面的考虑
David Cipolla1, Christopher J Gruenloh2, Nani Kadrichu3
1Research Department, Insmed Incorporated, Bridgewater, New Jersey, USA.
吸入式和鼻腔生物制剂 (INBs) 与注射剂相比具有优势,但需要仔细开发. 本报告通过讨论化学,制造和控制 (CMC) 和生物等价性 (BE) 考虑来指导INB的发展.
科学领域:
- 制药科学 制药科学
- 生物技术是生物技术.
- 监管科学 监管科学
背景情况:
- 大分子和生物制剂的吸入和鼻腔输送提供了直接准,绕道代谢和方便.
- 观察到可吸入和鼻腔生物制剂 (INBs) 的研究和开发显著增长.
- 为了进入INB市场,必须解决配方,制造,分析测试和监管审查方面的挑战.
研究的目的:
- 总结有关将化学,制造和控制 (CMC) 和生物等价性 (BE) 原则应用于INB开发的专家讨论.
- 在没有明确指导的情况下,审查适用的INB文献和监管指南.
- 探索INB要求与已建立的医疗气溶技术之间的平衡.
主要方法:
- 审查现有的美国FDA和EMA关于生物药物和小分子吸入/鼻产品的指导方针.
- 综合了2023年国际气溶医学协会 (ISAM) 和国际制药气溶联盟关于法规和科学 (IPAC-RS) 研讨会的讨论.
- 包括最近的发展和关于仿制,吸入生物制剂和基于病毒的产品的案例研究.
主要成果:
- 对INB发展的监管期望的描述.
- 关于为INB选择交付系统和配方类型的指导.
- 对评估INB产品质量属性的分析技术的概述.
结论:
- INBs对治疗未满足需求的疾病和减少注射负担充满希望.
- 研究人员,开发人员和监管机构之间的持续合作对于推进INB疗法至关重要.
- 成功开发和监管批准INB最终将使患者受益并改善健康结果.
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