患有非酒精性硬性肝炎的患病和与非酒精性硬性肝炎相关的危险因素在治疗氧化氨酸的风湿性关节炎患者中:基于人口的研究
Antoine Boustany1, Somtochukwu Onwuzo2, Adejoke Johnson3
1Division of Gastroenterology, Department of Medicine, University of Florida College of Medicine, Jacksonville, Florida, USA.
Arquivos de gastroenterologia
|April 8, 2025
概括
服用氧化 (HCQ) 的类风湿性关节炎患者患非酒精性脂肪肝炎 (NASH) 的风险更高. 临床医生应监测这些患者的肝病.
科学领域:
- 肝病学 肝病学是一种肝病学.
- 类风湿病学 类风湿病学
- 药理学 药理学是指药理学的学科.
背景情况:
- 非酒精性脂肪肝炎 (NASH) 是美国肝病的日益严重的原因.
- 类风湿性关节炎 (RA) 影响着全球大量人口,氧化 (HCQ) 是一种常见的治疗方法.
- 对于HCQ对NASH发展的影响尚未完全理解.
研究的目的:
- 检查使用HCQ治疗的RA患者中NASH的患病率和风险因素.
- 调查HCQ使用与RA患者NASH发展之间的关联.
主要方法:
- 从美国多中心数据库 (1999-2022) 中对619,350名成年RA患者进行了回顾性队列研究.
- 多变量回归分析被用来评估纳什风险,调整吸烟,性别,失脂症,高血压,糖尿病,肥胖和HCQ使用等混因素.
主要成果:
- 接受HCQ治疗的RA患者与未接受HCQ治疗的患者相比,NASH的患病率更高.
- 增加NASH风险与吸烟,男性性别,脂质不良,高血压,2型糖尿病,肥胖和HCQ使用有关 (OR: 1.79; 95%CI: 1.65-1.94).
结论:
- 使用HCQ的RA患者患上NASH的患病率和几率增加.
- HCQ可能有助于肝硬化症和纤维化症的发展,需要对预防肝病进行临床考虑.
- 建议进行进一步的研究,以获得最佳的查和改善患者的治疗结果.
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