性和睡眠质量影响睡眠障碍与疼痛敏感性之间的关系
Elisabet Dortea Ragnvaldsdóttir Joensen1, Laura Frederiksen1, Signe Vindbæk Frederiksen1
1Faculty of Medicine, Aalborg University, Aalborg, Denmark.
European journal of pain (London, England)
|April 8, 2025
概括
睡眠障碍对男性和女性的疼痛敏感性有不同的影响. 基线睡眠质量没有改变这些疼痛反应,但在睡眠中断后确实影响了自我报告的睡眠质量.
科学领域:
- 疼痛研究 疼痛研究
- 睡眠科学 睡眠科学
- 健康中的性别差异
背景情况:
- 慢性疼痛影响全球20%的人口.
- 睡眠质量是影响慢性疼痛的一个已知的因素.
- 性别和基线睡眠质量对睡眠障碍对疼痛敏感性的影响的影响尚不清楚.
研究的目的:
- 调查性行为如何影响睡眠障碍和疼痛敏感性之间的关系.
- 为了确定基线睡眠质量是否能缓和睡眠障碍对疼痛敏感性的影响.
- 为了检查三个晚上睡眠障碍对健康个体疼痛敏感性的影响.
主要方法:
- 59名健康参与者 (30名女性) 接受了两次实验室试验.
- 在会议之间三天晚上诱导睡眠障碍.
- 使用定量感官测试 (QST) 评估疼痛敏感度,包括袖口和手持算法.
- 睡眠质量,影响和疼痛灾难性被通过问卷测量.
- 客观睡眠模式使用手腕动图和睡眠日记来监测.
主要成果:
- 男性在睡眠中断后表现出缓解时间总结的疼痛 (p < 0.01).
- 在超值刺激 (p < 0.01) 后,女性经历了疼痛增加.
- 根据基线睡眠质量,没有观察到QST参数的显著差异.
- 具有良好基线睡眠的参与者在干扰后的超值刺激期间报告了更高的疼痛 (p <0.05).
- 无论是起初睡眠良好还是不良的人均报告睡眠质量降低和睡眠中断后的休息 (p < 0.05).
结论:
- 睡眠障碍可能会对男性和女性的疼痛敏感性产生不同的影响.
- 基线睡眠质量似乎对睡眠中断后客观疼痛敏感度变化的影响有限.
- 睡眠障碍协议有效地模仿慢性疼痛患者经历的睡眠障碍,突出性别特异性反应.
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