癌的预后指标和生存率:从一个回顾性研究的见解
Tharinee Rahong1, Panitta Sitthinamsuwan2, Suchanan Hanamornroongruang2
1Department of Obstetrics and Gynecology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.
概括
在癌中,无进展的存活率因同时存在的病变,淋巴血管入侵,淋巴结转移和p53阳性而恶化. 瘤大小超过4厘米会影响整体存活率.
科学领域:
- 妇科瘤学 妇科瘤学
- 癌症研究 癌症研究
- 病理学 病理学 病理学
背景情况:
- 癌的预后受到各种临床和病理因素的影响.
- 确定可靠的预后指标对于患者管理和治疗分层至关重要.
研究的目的:
- 在癌患者中确定无进展生存 (PFS) 和整体生存 (OS) 的预后指标.
- 在这个患者队列中建立PFS和OS的可量化的措施.
主要方法:
- 对104名癌患者的医疗记录 (2006-2020年) 进行了回顾性分析.
- 对患者特征,手术结果和免疫组织化学标志物的评估 (p16,p53,PD-L1).
主要成果:
- 四个因素显著与PFS的恶化有关:共存的部病变,淋巴血管空间入侵 (LVSI),淋巴结转移,和积极的p53状态.
- 瘤大小>4厘米显著相关于下降的OS (p=.001).
- 阳性p16或阴性p53免疫组织化学与显著改善的PFS和OS相关.
结论:
- 同时存在的部病变,阳性LVSI,淋巴结转移和阳性p53状态是PFS不利的预后因素.
- 超过4厘米的瘤直径是较差的OS的重要预测因素.
- 对于p16和p53的免疫组织化学概况,对于癌的生存结果具有预后价值.
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