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Updated: May 15, 2025

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SFRP1的上调会导致海马突触功能障碍和记忆障碍

Guadalupe Pereyra1, María Inés Mateo1, Pablo Miaja1

  • 1Centro de Biología Molecular Severo Ochoa, CSIC-UAM, Campus de la Universidad Autónoma de Madrid, 28049 Madrid, Spain; CIBER de Enfermedades Raras (CIBERER), 28029 Madrid, Spain.

Cell reports
|April 8, 2025
PubMed
概括

在阿尔茨海默病 (AD) 中SFRP1升高会损害神经元功能,导致早期突触缺陷和认知衰退. 这突出了AD病变发生中的质因子,并表明了在前进性AD中发生突触的机制.

关键词:
亚当10 亚当10 亚当阿尔茨海默氏症是阿尔茨海默氏症的一种疾病.科普:神经科学是什么意思星球细胞是星球细胞.树枝状的棘 树枝状的棘微质细胞中的微质细胞这是一种神经毒素 (neurexin).神经退行症的神经退行症蛋白质组学 蛋白质组学结构性的突触分子.突触性可塑性 突触性可塑性

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