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Ayya Keshet¹, Ori Hochwald², Amit Lavon¹

¹Department of Computer Science and Applied Mathematics, Weizmann Institute of Science, Rehovot, Israel; Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot, Israel.

|April 8, 2025

概括

抗生素破坏了早产婴儿的肠道微生物组,增加了抗生素耐药性. 人母乳养促进有益细菌并减少耐药性,强调需要谨慎使用抗生素和支持母乳养.

科学领域:

新生儿护理新生儿护理
微生物组研究微生物组研究
儿科健康儿科健康

背景情况:

过早分娩对婴儿的生存和长期健康构成重大风险.
肠道微生物组对婴儿发育至关重要,但在早产婴儿中经常有失调.
了解抗生素对早产肠道微生物群的影响至关重要.

研究的目的:

分析抗生素暴露对肠道微生物组合和早产婴儿抗生素耐药性的影响.
调查养模式,特别是母乳对正在发育的早产肠道微生物群的影响.
评估抗生素治疗后肠道微生物组和抗生素耐药性的时间变化.

主要方法:

对100名早产婴儿每周,6个月和1年的便样本进行分析.
微生物组数据与有关抗生素使用和养实践的临床信息的相关性.
在有或没有经验性抗生素治疗的婴儿之间比较肠道微生物组概况.

主要成果:

抗生素的使用导致了肠道微生物组合的显著改变,并在生命早期增加了抗生素耐药性基因丰富度.
这些微生物组变化和抗药性增加随着时间的推移而减少,但长期的临床影响尚不确定.
人类母乳养与有益的微生物群有关,如Actinobacteriota,并减少了抗生素耐药性的基因.

结论:

在新生儿重症监护中,明智的抗生素使用至关重要,以减轻对婴儿肠道微生物群的负面影响.
促进母乳养可以促进更健康的肠道微生物群,并可能抵消抗生素诱导的失生症.
需要进一步的研究来澄清早期抗生素暴露和早产婴儿微生物组变化的长期临床后果.

关键词:

CP: 微生物学微生物学抗生素抗生素是一种抗生素.抗生素耐药性抗生素耐药性婴儿婴儿婴儿婴儿婴儿微生物组是一个微生物组.预产期前的时间.

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