响应性和单相性狼性炎:流行率,关联和结果
Fadi Kharouf1, Pankti Mehta1, Virginia Carrizo-Abarza1
1University of Toronto Lupus Clinic, Division of Rheumatology, Schroeder Arthritis Institute, Krembil Research Institute, University Health Network, Toronto, ON, Canada.
Rheumatology (Oxford, England)
|April 8, 2025
概括
大约26%的狼性炎 (LN) 患者表现出响应性和单相性疾病过程. 然而,很难预测这种结果,一些患者仍然面临长期不良事件.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學專業.
- 类风湿病学 类风湿病学
- 免疫学 免疫学 免疫学
背景情况:
- 狼性炎 (LN) 是系统性红斑狼 (SLE) 的严重并发症,经常导致严重的损伤.
- 虽然一些LN患者经历了有利的,自我限制的疾病过程,但这不是常态.
研究的目的:
- 确定具有响应性和单相性疾病过程的LN患者的比例.
- 确定与这种有利结果相关的基线特征.
- 评估LN患者的长期预后,以响应性和单相疗程.
主要方法:
- 从观察队列中对SLE患者进行回顾性分析,这些患者患有LN.
- 通过蛋白尿的恢复在1-2年内没有随后的爆发而定义的响应性和单相过程.
- 使用后勤和考克斯回归来分析基线预测因素和长期结果 (ESKD,eGFR下降,死亡).
主要成果:
- 在374名LN患者中,25.7%的患者有响应性和单相疗程.
- 年龄较大和在LN发病时SLE持续时间较短与这种过程有关.
- 蛋白尿恢复和没有爆发与不良结果的减少相关,但18.8%仍然经历了不良事件.
结论:
- 响应性和单相性过程发生在约26%的LN患者中.
- 预测这种有利的轨迹仍然具有挑战性.
- 即使看似良好的初始反应,显著的少数LN患者面临长期的并发症.
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