分子过敏学:在食物过敏的过敏原特异性免疫疗法中发现和应用Epitope

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Fei Huan¹, Shuai Gao¹, Yi Gu¹

¹College of Ocean Food and Biological Engineering, Xiamen Key Laboratory of Marine Functional Food, Fujian Provincial Engineering Technology Research Center of Marine Functional Food, Jimei University, Xiamen, 361021, Fujian, China.

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概括

识别食物过敏原表位物有助于推进过敏原特异性免疫疗法 (AIT). 这项研究指导了低过敏剂的设计,以减少食物过敏 (FA) 的严重程度,并改善治疗结果.

科学领域:

分子过敏学分子过敏学
免疫治疗是一种免疫疗法.
生物信息学是一种生物信息学.

背景情况:

食物过敏 (FA) 患病率上升显著影响公众健康和生活质量.
过敏原特异性免疫疗法 (AIT) 研究重点是表位标识和低过敏原剂设计.

研究的目的:

从分子过敏学角度审查食物过敏原.
概述生物信息学和实验验证的集成,用于表位标识.
为AIT指南使用表位信息设计的低过敏剂突出显示.

主要方法:

对T/B细胞表位标识的过敏原氨基酸序列和结构的特征.
确定表位的对齐,以揭示T/B细胞表位之间的最小重叠.
通过合成,基因工程和食品加工开发低过敏剂.

主要成果:

分子水平的表征有助于T/B细胞表位标识.
T/B细胞表位体之间的最小序列重叠为设计过敏原分子提供了数据.
低过敏剂是通过各种方法开发的,新的策略如DNA疫苗正在出现.

结论:

操纵抗原表位减少了过敏性,创造了低过敏剂,以最大限度地减少AIT的副作用.
有效的AIT需要确定长期免疫耐受性的最佳剂量和持续时间.
本综述为在食物过敏治疗中应用低过敏剂提供了指导.

关键词:

过敏原特定免疫疗法 B细胞表皮图是B细胞表皮图.食物过敏食物过敏低过敏性药物过敏性药物分子过敏学分子过敏学 T细胞表皮图是T细胞表皮图.

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