经典猪瘟病毒的全球人口动态和进化选择 完整的基因组:贝叶斯凝聚分析的见解
Roopa Mahadevaswamy1, Vijay Muruganantham1, Varsha Ramesh1
1ICAR-National Institute of Veterinary Epidemiology and Disease Informatics, Yelahanka, Bengaluru, Karnataka, 560 064, India.
Virus genes
|April 8, 2025
概括
经典猪瘟病毒 (CSFV) 对猪业构成全球威胁. 我们的研究揭示了CSFV中持续的积极选择,可能导致新的,高度毒性菌株的出现.
科学领域:
- 兽医病毒学 兽医病毒学
- 分子进化分子进化
- 基因组学就是基因组学.
背景情况:
- 经典猪瘟病毒 (CSFV) 是一种高度传染性的RNA病毒,由于高死亡率和发病率,在全球猪业造成重大经济损失.
- 以前对CSFV的基因组研究往往在地理上受到限制,或专注于特定的基因区域,阻碍了对其全球演变的全面理解.
研究的目的:
- 用全面的全基因组数据集分析古典猪瘟病毒 (CSFV) 的全球遗传多样性和进化模式.
- 调查进化速率并确定对CSFV产生选择压力,以了解其未来出现的潜力.
主要方法:
- 利用了来自NCBI的220个CSFV全基因组序列的精心策划的全球数据集,并补充了来自作者实验室的两个序列.
- 采用贝叶斯系遗传分析来估计进化速率和最近的共同祖先 (tMRCA) 的时间.
- 进行了选择压力分析,以检测对CSFV基因组起作用的多样化正选择.
主要成果:
- 估计CSFV的平均替代率为2.06 × 10-3替代/地点/年,估计tMRCA在1877年.
- 在分析的数据集中确定了两个中国原产的CSFV序列.
- 揭示了普遍和偶发的积极选择,表明正在进行的多样化自然选择可能会促进遗传多样性和新的CSFV血统的出现.
结论:
- 这些发现突显了CSFV的动态演变,有证据表明正在进行的积极选择推动了遗传多样性.
- 了解这些进化动态,包括新血统出现的可能性,对于开发有效的对抗CSFV的控制战略至关重要.
- 该研究为未来对管理新出现的CSFV基因型的策略的评估提供了有价值的见解,对猪健康和经济有很大的影响.
相关概念视频
Mutation, Gene Flow, and Genetic Drift
57.6K
In a population that is not at Hardy-Weinberg equilibrium, the frequency of alleles changes over time. Therefore, any deviations from the five conditions of Hardy-Weinberg equilibrium can alter the genetic variation of a given population. Conditions that change the genetic variability of a population include mutations, natural selection, non-random mating, gene flow, and genetic drift (small population size).
57.6K
What is Population Genetics?
57.1K
A population is composed of members of the same species that simultaneously live and interact in the same area. When individuals in a population breed, they pass down their genes to their offspring. Many of these genes are polymorphic, meaning that they occur in multiple variants. Such variations of a gene are referred to as alleles. The collective set of all the alleles within a population is known as the gene pool.
57.1K
Gene Flow
34.4K
Gene flow is the transfer of genes among populations, resulting from either the dispersal of gametes or from the migration of individuals.
34.4K
Evolutionary Relationships through Genome Comparisons
5.6K
Genome comparison is one of the excellent ways to interpret the evolutionary relationships between organisms. The basic principle of genome comparison is that if two species share a common feature, it is likely encoded by the DNA sequence conserved between both species. The advent of genome sequencing technologies in the late 20th century enabled scientists to understand the concept of conservation of domains between species and helped them to deduce evolutionary relationships across diverse...
5.6K
Viral Mutations
32.1K
A mutation is a change in the sequence of bases of DNA or RNA in a genome. Some mutations occur during replication of the genome due to errors made by the polymerase enzymes that replicate DNA or RNA. Unlike DNA polymerase, RNA polymerase is prone to errors because it is not capable of “proofreading” its work. Viruses with RNA-based genomes, like HIV, therefore accrue mutations faster than viruses with DNA-based genomes. Because mutation and recombination provide the raw material...
32.1K
Viral Recombination
23.1K
Cells are sometimes infected by more than one virus at once. When two viruses disassemble to expose their genomes for replication in the same cell, similar regions of their genomes can pair together and exchange sequences in a process called recombination. Alternatively, viruses with segmented genomes can swap segments in a process called reassortment.
23.1K


