在患有急性淋巴细胞白血病的儿童中预防甲德酸诱导的粘膜炎的谷氨酸口水:一个随机交叉试验
S Siva Sankaran1, Pooja Dewan2, Rajeev Kumar Malhotra3
1Department of Pediatrics, University College of Medical Sciences and Guru Teg Bahadur Hospital, Dilshad Garden, Delhi, 110095, India.
谷氨酸口水显著减少严重的口腔粘膜炎,持续时间和疼痛在急性淋巴细胞白血病 (ALL) 接受高剂量甲状腺素 (HDMTX) 治疗的儿童. 这种干预在癌症治疗期间提供了更好的舒适性.
科学领域:
- 在瘤学瘤学.
- 儿科血液学 儿科血液学
- 口腔医学是指口腔医学.
背景情况:
- 急性淋巴细胞白血病 (ALL) 的治疗通常涉及高剂量的甲状腺素 (HDMTX).
- HDMTX可以引起严重的口腔粘膜炎,这是一个痛苦的疾病,影响生活质量.
- 标准口腔卫生协议 (SOHP) 可能无法完全预防或减轻粘膜炎.
研究的目的:
- 为了评估与SOHP相比,谷氨胺口水的疗效.
- 评估对口腔粘膜炎的发病率,持续时间和严重程度的影响.
- 在接受HDMTX的儿科ALL患者中测量与粘膜炎相关的疼痛.
主要方法:
- 一项随机交叉试验,涉及接受HDMTX的儿科ALL患者.
- 患者在交替治疗过程中接受了谷氨胺口水加SOHP或单独SOHP.
- 使用WHO标准对口腔粘膜炎的严重程度进行了分级,并使用Wong-Baker FACES疼痛评分表来评估疼痛.
主要成果:
- 谷氨胺口水显著降低了严重粘膜炎的发生率 (3.1%对44%,P<0.001).
- 谷氨胺组的粘膜炎总体持续时间较短 (2天与5天相比,P<0.001).
- 谷氨酸组的中位疼痛评分显著较低 (4.5比8,P<0.001).
结论:
- 在HDMTX治疗期间,胺口水有效减轻严重的口腔粘膜炎.
- 它显著减少了儿科ALL患者的粘膜炎持续时间和相关疼痛.
- 这种干预改善了患者的舒适度和治疗体验.
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