银杏花药物相互作用对出血风险和凝血概况的影响:综合分析
Ngo Thi Quynh Mai1, Nguyen Viet Hieu1, Tran Thi Ngan1,2
1Faculty of Pharmacy, Hai Phong University of Medicine and Pharmacy, Hai Phong, Vietnam.
PloS one
|April 8, 2025
概括
银杏花提取物与常见药物相互作用,增加出血风险并影响凝血. 对这些药物相互作用进行仔细的临床评估对于患者的安全至关重要.
科学领域:
- 药理学 药理学是指药理学的学科.
- 临床医学 临床医学
- 草药研究 草药研究
背景情况:
- 银杏花提取物被广泛使用,但其潜在的药物相互作用,特别是关于出血风险和凝血的可能性,需要进行彻底的调查.
- 了解这些相互作用对于安全的临床实践和患者的治疗结果至关重要.
研究的目的:
- 调查涉及金科比洛巴提取物药物相互作用的患病率和临床影响,以研究出血风险和凝血概况.
- 为了确定经常与金科比洛巴提取物相互作用的特定药物,并评估它们对血液静止的影响.
主要方法:
- 追溯观察性研究分析了2022年1月至2023年12月的患者数据.
- 纳入标准:年龄在18岁以上的患者,处方Ginkgo biloba提取物 (单独或与其他药物一起),有完整的医疗记录.
- 发病率,相关性分析和几率比率 (OR) 计算以评估药物相互作用,出血风险和凝血异常.
主要成果:
- 观察到12.94%的药物相互作用发生率涉及银杏花提取物.
- 与抗血小板药物 (如克洛皮多格雷尔,阿司匹林) 和NSAIDs经常发生相互作用.
- 银杏花提取物相互作用与增加的出血风险 (OR: 1.08) 和异常凝血 (OR: 1.49) 有显著的相关性.
结论:
- 银杏花提取物药物相互作用很普遍,并与显著的出血风险和凝血异常有关.
- 像克洛皮多格雷尔,阿司匹林和奥梅普拉这样的特定药物在与银杏花提取物联合处方时需要谨慎考虑.
- 临床实践必须优先评估潜在的Ginkgo biloba提取物相互作用,以减轻出血风险并有效管理凝血.
相关概念视频
Anticoagulant Drugs: Vitamin K Antagonists and Direct Oral Anticoagulants
1.1K
Oral anticoagulants are vital tools in preventing and treating blood clotting disorders. This diverse class of medications can be categorized as vitamin K antagonists, exemplified by warfarin, and direct thrombin inhibitors (DTIs), such as dabigatran, as well as factor Xa inhibitors, including rivaroxaban.
Warfarin, a prominent vitamin K antagonist family member, exerts its effect by inhibiting the enzyme VKORC1 (vitamin K epoxide reductase complex 1). By hindering this enzyme, warfarin...
Warfarin, a prominent vitamin K antagonist family member, exerts its effect by inhibiting the enzyme VKORC1 (vitamin K epoxide reductase complex 1). By hindering this enzyme, warfarin...
1.1K
Antiplatelet Drugs: Prostaglandin Synthesis, P2Y12 and Glycoprotein IIb/IIIa Inhibitors
417
Antiplatelet drugs emerge as frontline defenders against the insidious threat of thromboembolic diseases, where abnormal clots obstruct vital blood vessels. These drugs stand as bulwarks, inhibiting platelet aggregation and clot formation, thereby mitigating the risk of life-threatening conditions like myocardial infarction, coronary artery disease, and thrombotic strokes.
Prostaglandin synthesis inhibitors, exemplified by the widely known aspirin, wield their power by irreversibly acetylating...
Prostaglandin synthesis inhibitors, exemplified by the widely known aspirin, wield their power by irreversibly acetylating...
417
Anticoagulant Drugs: Low-Molecular-Weight Heparins
568
Hemostasis is a crucial process that prevents excessive blood loss from damaged blood vessels. It involves various mechanisms such as vasoconstriction, platelet adhesion and activation, and fibrin formation. The importance of each mechanism depends on the type of vessel injury. In contrast, thrombosis is the abnormal formation of a blood clot within the blood vessels, leading to potential complications if the clot obstructs blood flow. Thrombosis can be caused by increased coagulability of the...
568
Factors Affecting Protein-Drug Binding: Drug Interactions
71
Drug interactions are a critical aspect of pharmacology and can occur when two or more drugs compete for the same binding site. This competition can result in one drug displacing another, altering the effect of the displaced drug. Drug interactions are complex processes that rely heavily on how much of the displacer drug is present and how strongly it can bind to the same sites as the displaced drug.
Displacement interactions can have varying outcomes, ranging from toxicity to virtually...
Displacement interactions can have varying outcomes, ranging from toxicity to virtually...
71
Disorders of Hemostasis
658
Hemostasis, the process that stops bleeding after a blood vessel injury, is crucial for maintaining the integrity of the circulatory system. However, disorders of hemostasis can disrupt this delicate balance, leading to either excessive clotting or bleeding. These disorders can be broadly classified into thromboembolic disorders and bleeding disorders.
Thromboembolic Disorders
Two factors primarily cause thromboembolic conditions.
Thromboembolic Disorders
Two factors primarily cause thromboembolic conditions.
658
Chronopharmacokinetics: Circadian Rhythms and Influence on Drug Response
32
Circadian rhythms are cyclic changes that are crucial in plasma drug concentrations. Various standard circadian parameters, including core body temperature, heart rate, and other cardiovascular factors, directly impact disease states and the therapeutic response to drug therapy.
The time of drug administration is an important factor to consider, as it can influence the toxic dose of a drug. For example, a study conducted by Prins et al. in 1997 examined the effects of the timing of...
The time of drug administration is an important factor to consider, as it can influence the toxic dose of a drug. For example, a study conducted by Prins et al. in 1997 examined the effects of the timing of...
32


