母亲甲状腺过氧化酶抗体暴露与儿童的情绪和行为问题相关联
European thyroid journal
|April 8, 2025
概括
怀孕期间母亲甲状腺过氧化酶抗体 (TPOAb) 的阳性与儿童的情绪和行为问题有关. 第三季度的TPOAb阳性增加了女孩的行为问题,而第一季度的阳性减少了男孩的亲社会行为.
科学领域:
- 产科和妇科 产科和妇科
- 儿科心理学 儿科心理学
- 内分泌学 在内分泌学.
背景情况:
- 母体甲状腺过氧化酶抗体 (TPOAb) 阳性与妊娠并发症和对后代潜在的神经发育影响有关.
- 了解这些关联对于早期干预和改善儿童结果至关重要.
研究的目的:
- 调查怀孕期间母亲TPOAb水平与学龄前儿童的情绪和行为问题之间的联系.
- 为了确定TPOAb阳性的时间是否会影响儿童的特定行为结果.
主要方法:
- 采用了队列研究设计,其中包括来自中国马安山出生队列的2,464对母婴.
- 母亲的TPOAb和FT4水平是从怀孕期间采集的血液样本中追溯测量.
- 4岁儿童的情绪和行为问题使用"优势和困难问卷"进行评估.
主要成果:
- 第三个三个月的孕妇TPOAb阳性与女孩的行为问题风险增加有关 (OR: 2.190).
- 第一个三个月的母亲TPOAb阳性与男孩亲社会行为的发病率降低有关 (OR:0.451).
结论:
- 怀孕期间母亲TPOAb阳性可能与学龄前儿童的特定情绪和行为问题有关.
- 母亲TPOAb阳性的时间似乎影响了后代观察到的行为结果的性质.
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