体重增加,减肥和2型糖尿病风险:来自社区动脉样硬化风险 (ARIC) 研究的证据
Samaneh Asgari1, Soroush Masrouri1, Davood Khalili1
1Prevention of Metabolic Disorders Research Center, Research Institute for Metabolic and Obesity Disorders, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Endocrinology, diabetes & metabolism
|April 8, 2025
概括
体重增加显著增加2型糖尿病的风险. 虽然减肥最初可能看起来是有益的,但考虑到所达到的体重,其保护作用会减弱. 这凸显了体重管理在预防糖尿病中的重要性.
科学领域:
- 流行病学 流行病学
- 代谢健康 代谢健康
- 公共卫生 公共卫生
背景情况:
- 2型糖尿病 (T2DM) 是北美和加勒比地区的重大健康问题.
- 体重变化对T2DM发病率的影响,考虑到初始体重与达到的体重,需要进一步调查.
研究的目的:
- 评估3年体重变化对美国成年人6年随访期间T2DM发病率的影响.
- 根据初始体重与观察期结束时的体重来区分体重变化的影响.
主要方法:
- 从社区动脉样硬化风险 (ARIC) 研究中分析了8377名参与者 (年龄在45-64岁),在基线时没有T2DM和癌症.
- 将参与者分为体重变化组的分类:≥5%的减肥,稳定 (±5%) 和≥5%的增肥,基于~3年间隔的测量.
- 使用Cox的比例危险模型,对共变量进行调整,以评估T2DM事件的风险.
主要成果:
- 当调整为初始体重时,体重增加 (≥5%) 与增加T2DM风险 (HR: 1.68) 有着强有力的关联.
- 体重减轻 (≥5%) 在调整为初始体重时显示了降低T2DM风险的趋势 (HR:0.73),但在调整为达到体重 (HR:0.84) 时失去了意义.
- 体重增加 (≥5%) 仍然是T2DM (HR: 1.51) 的重要危险因素,即使在调整体重后.
结论:
- 体重增加是发展2型糖尿病的持续风险因素.
- 体重减轻对T2DM发病率的明显保护作用在考虑到个体所获得的体重时显著减少.
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