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对于复发性/耐火性多发性骨髓瘤的标准护理Idecabtagene Vicleucel:一个CIBMTR分析
Surbhi Sidana1, Nausheen Ahmed2, Othman Salim Akhtar3
1Stanford University, Palo Alto, California, United States.
Blood
|April 8, 2025
概括
护理标准idecabtagene vicleucel (ide-cel) CAR T细胞疗法在多发性骨髓瘤患者中显示出现实世界的有效性和安全性,甚至与并发性疾病相匹配的临床试验结果.
科学领域:
- 在瘤学瘤学.
- 免疫治疗是一种免疫疗法.
- 血液学 血液学 血液学
背景情况:
- idecabtagene vicleucel (ide-cel) 是第一个经FDA批准的针对多发性骨髓瘤的CAR T细胞疗法.
- 临床试验往往具有严格的资格标准,限制了现实世界的适用性.
研究的目的:
- 在现实世界多发性骨髓瘤患者群体中评估标准护理 (SOC) ide-cel 的安全性和有效性.
- 将现实世界的结果与临床试验的结果进行比较.
主要方法:
- 从CIBMTR注册表获得SOC ide-cel的821名患者的回顾性分析.
- 评估患者的人口统计,并发症,先前的治疗方法和治疗结果.
主要成果:
- 总体响应率 (ORR) 为73%,完全响应率 (CR) 为25%.
- 无进展生存 (PFS) 的中位数为8.8个月;与治疗相关的死亡率为6%.
- 观察到高率的细胞因子释放综合征 (80%) 和神经毒性 (28%),大多是低级的.
结论:
- SOC ide-cel在现实世界多发性骨髓瘤患者中显示出有利的安全性和有效性.
- 结果反映了临床试验数据,即使是在经常被排除在试验之外的具有重大并发症的患者中.
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