用Cirsium japonicum DC提取物加载的无布进行排泄管理,可增强血静和伤口愈合
Liying Zou1, Jingjun Dong2, Ruyi Xie1
1Shandong Key Laboratory of Medical and Health Textile Materials, Laboratory for Manufacturing Low Carbon and Functionalized Textiles in the Universities of Shandong Province, College of Textiles & Clothing, Qingdao University, Qingdao 266071, China.
Colloids and surfaces. B, Biointerfaces
|April 8, 2025
概括
一种与Cirsium japonicum DC提取物 (CJDC@CS-VIS-PET) 注入的新型奇托桑-糖-聚复合材料无布显示出高级伤口愈合应用的优越抗菌,抗氧化和静血性质.
科学领域:
- 生物材料科学 生物材料科学
- 织工程 织工程 织工程
- 伤口护理技术 伤口护理技术
背景情况:
- 开发先进的伤口带对于有效的愈合至关重要.
- 复合无布为生物医学应用提供独特的特性.
- 自然提取物可以增强生物材料的功能.
研究的目的:
- 为了创建一个多功能伤口带使用基托桑-糖-聚复合材料无布.
- 将Cirsium japonicum DC提取物 (CJDC) 纳入,以赋予抗菌,抗氧化和静血能力.
- 在伤口愈合和生物相容性方面评估开发的伤口带的性能.
主要方法:
- 用于制备素-粘合剂-聚 (CS-VIS-PET) 复合无织品的针刺技术.
- 喷涂Cirsium japonicum DC提取物 (CJDC) 在无布的CS层上.
- 评估抗氧化剂率,对大肠杆菌和黄金杆菌的抗菌疗效,以及静血能力.
- 评估空气透性,水蒸气透性,伤口排泄物管理和伤口愈合率.
- 生物相容性测试包括血液和细胞相容性.
主要成果:
- 10%的CJDC@CS-VIS-PET复合无布呈现了87.3%的抗氧化剂率.
- 对大肠杆菌和金黄色杆菌的抗菌率分别达到99.5%和99.7%.
- 通过涉及复合层和CJDC的协同机制实现了出色的静血能力.
- 包裹证明了有效的伤口排泄物管理和92%的伤口愈合率在第14天.
- 由于材料的固有生物相容性,观察到出色的血液和细胞兼容性.
结论:
- 开发的三明治结构的CJDC@CS-VIS-PET无布是一种有前途的多功能伤口包裹.
- 该材料有效地管理伤口环境,促进愈合,并表现出强大的抗微生物和静血性质.
- 这种复合无布为未来开发先进的伤口护理解决方案提供了宝贵的参考.
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