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在心房动下,在左心房附属部分的血栓形成,生长和栓塞的建模

Anna Maria Lo Presti¹, Alessandra Monteleone², Giulio Musotto²

¹University of Palermo, Department of Engineering, Palermo, Italy; Ri.MED Foundation, Palermo, Italy.

Computers in biology and medicine

|April 8, 2025

概括

这项研究模型使用流体动力学在心房动 (AF) 中留下心房附属体 (LAA) 血栓. 它揭示了血栓形成始于LAA尖端,突出了栓塞和临床并发症的风险.

科学领域:

心血管研究研究心血管研究
生物医学工程生物医学工程
计算流体动力学的流体动力学.

背景情况:

左心房尾 (LAA) 血栓是心房动 (AF) 的重要并发症,增加缺血事件的风险.
在LAA中形成血栓可以导致栓塞,导致严重的循环功能障碍和临床问题.

研究的目的:

在AF条件下模拟患者特定LAA形态中的血栓形成和行为.
阐明LAA血栓发育和迁移的血液动力学和生物化学驱动因素.
为了提高对AF患者血栓栓塞风险机制的理解.

主要方法:

利用基于光滑粒子水力动力学的创新流体结构相互作用模型.
通过追踪凝血级联组件,模拟了凝血过程.
根据生化和血液动力学触发器,将液体颗粒转化为固体相.

主要成果:

模拟确定了从LAA尖端开始的血栓形成,通过叶片和沟进展.
观察到,凝块的生长在内部向高循环区域前进.
这项研究突出了容易发生凝块生长,栓塞和碎片化的特定区域.

结论:

精确预测血栓的形成,生长和碎片化,为AF相关的血栓栓塞风险提供了关键的见解.
了解这些机制对于开发有针对性的疗法来减少AF患者的血栓栓塞事件至关重要.
计算模型为研究LAA血栓形成和指导临床策略提供了有价值的工具.

关键词:

心房动 (AF) 是一种心房动.流体结构相互作用 (FSI)左心房附属体 (LAA) 是一个左心房附属体.抛光粒子水力动力学 (SPH)发生血栓栓塞的风险形成了血栓的形成.

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