循环多不和脂肪酸的百分比和冠状动脉疾病的发病率和死亡率:观察和门德尔随机化分析
Qiuxuan Liu1, Yifan Kong1, Haonan Kang1
1Department of Epidemiology and Biostatistics, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, 430030, China.
高水平的多可萨赫萨酸 (DHA) %可以防止冠状动脉疾病 (CAD) 的死亡率,特别是在老年人中. 欧米茄-6%显示了预防CAD事件的性别特异性益处. 年龄和性别对于基于PUFA的CAD预防策略至关重要.
科学领域:
- 心血管研究研究心血管研究
- 营养流行病学 营养流行病学
- 遗传流行病学遗传流行病学
背景情况:
- 多不和脂肪酸 (PUFA) 在预防冠状动脉疾病 (CAD) 中的作用受到争议.
- 调查流通的PUFA百分比和CAD结果对于公共卫生至关重要.
研究的目的:
- 检查循环多不和脂肪酸 (PUFA) 百分比与冠状动脉疾病 (CAD) 结果之间的关联.
- 用观察和门德尔随机化 (MR) 方法进行可靠的分析.
主要方法:
- 分析了来自203,373名没有基线CAD的英国生物库数据.
- 评估四个PUFA百分比 (DHA%,omega-3%,LA%,omega-6%) 与发生的CAD和CAD死亡率相比.
- 一样本和两样本MR的应用,包括线性,非线性,单变量和多变量方法,按年龄和性别分层.
主要成果:
- 观察数据显示,所有PUFA百分比和CAD结果之间存在反向关联.
- 一个样本的MR显示,基因预测的高DHA%显著降低了CAD死亡风险,特别是在老年人 (≥58岁).
- 基因预测的omega-6%与降低事件CAD风险有关,在女性中观察到显著效应,但在男性中没有. 两个样本的MR证实了这些发现,部分通过脂质通路进行调解.
结论:
- 增加的多可萨赫萨酸 (DHA) %可以防止CAD的死亡率,特别是在老年人中.
- 欧米茄-6%表明性别特异的反向关联与发生的CAD.
- 未来包括PUFA在内的CAD预防策略应考虑年龄和性别特异性影响.
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