炎症和抗炎性细胞因子双向调节调节焦虑的杏仁体电路
Byeongjun Lee1, Jeong-Tae Kwon1, Yire Jeong1
1The Picower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
Cell
|April 8, 2025
概括
通过对特定的大脑神经元的作用来调节焦虑. 促炎性细胞因子 (交白素-17A/C) 和抗炎性细胞因子 (交白素-10) 都会影响基底桃体中的神经元刺激性和行为.
科学领域:
- 神经免疫学
- 行为神经科学
- 分子精神病学
背景情况:
- 边缘免疫分子,如细胞因子,影响情绪和行为.
- 细胞因子影响大脑功能的精确神经回路在很大程度上是未知的.
- 在自身免疫或传染性疾病的炎症发作可能导致持续的情绪变化.
研究的目的:
- 研究细胞因子如何调节与焦虑相关的行为.
- 确定细胞因子在大脑中的特定神经回路.
- 阐明细胞因子信号在调节内部状态中的作用.
主要方法:
- 研究了细胞因子对基底桃体 (BLA) 神经元刺激性的影响.
- 研究了介质蛋白-17A (IL-17A),介质蛋白-17C (IL-17C) 和介质蛋白-10 (IL-10) 对BLA神经元功能的影响.
- 使用抗白素-17受体A (IL-17RA) 抗体并评估由此产生的行为变化.
主要成果:
- 细胞因子作为神经调节剂,通过BLA中的受体表达神经元调节焦虑.
- 升高的IL-17A和IL-17C水平增加了BLA神经元的刺激性,并促进了焦虑.
- 互白素-10 (IL-10) 对BLA神经元的兴奋性和行为产生了相反的影响.
- 同一个BLA神经元群中的细胞因子受体 (IL-17RA/ RE和IL-10受体) 调解这些效应.
结论:
- 通过特定的BLA神经元群体双向调节细胞因子信号.
- 炎症性和抗炎症性细胞因子直接影响控制内部状态的神经基质.
- 这项研究突显了外周炎症与大脑功能和行为改变的直接机制.
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