优化接受动脉手术的患者的二次预防:评估脂质降低疗法和抗血栓治疗的队列研究 奇数页面运行标题:心血管预防 动脉手术患者的心血管预防药物
Jing Yi Kwan1, Alex Harper2, Mehak Sood2
1The Leeds Vascular Institute, Leeds General Infirmary, Leeds Teaching Hospitals NHS Trust, Leeds, UK; The Leeds Institute of Cardiovascular and Metabolic Medicine, School of Medicine, University of Leeds, Leeds, UK.
概括
关动脉疾病的指导指导医疗 (GDMT) 在住院干预期间增加,但在中风前不充分使用降脂疗法 (LLT) 是一个问题. 为了降低心血管风险,需要长期的社区管理.
科学领域:
- 心血管医学 心血管医学
- 干预心脏病学 干预心脏病学
- 药物治疗 药物治疗
背景情况:
- 英国和欧洲的指导方针主张对动脉样硬化性动脉疾病进行最佳心脏保护性医疗治疗.
- 这包括抗血小板药物和降脂疗法 (LLT).
- 在接受动脉干预的患者中,指南导向医学治疗 (GDMT) 和低密度脂蛋白胆固醇 (LDL-C) 水平需要探索.
研究的目的:
- 调查GDMT的外科处方和定位.
- 在接受动脉干预的患者中评估LDL-C水平.
- 确定心血管风险管理需要改进的领域.
主要方法:
- 在2017年1月至2021年12月期间,对260名接受动脉干预的患者进行了单中心队列研究.
- 从电子医院记录中收集的数据包括人口统计,并发病,抗血小板和LLT处方以及胆固醇结果.
- 分析了四个时间点:索引前的事件,入学,免费和一年后续.
主要成果:
- 抗血小板治疗适用于20%的患者,高强度LLT适用于39%的患者,这些患者以前没有服用心脏保护药物.
- 抗血栓治疗 (82%至100%) 和LLT (88%至94%) 的处方从入院到出院显著增加.
- 平均LDL-C从服用前的2.2mmol/L下降到一年后的1.8mmol/L (p=0.026),但只有53%的人达到<1.8mmol/L的目标.
结论:
- 在发生中风之前,LLT的不足利用是一个重要的,可解决的问题.
- 冠状动脉干预的入院增加了GDMT,降低了LDL-C,但长期的社区管理至关重要.
- 需要改进心血管风险评估,LLT启动/升级以及定期监测LDL-C.
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