周围炎症和身体质量指数之间的关联与双极II型抑郁症中白质完整性和自由水的相关性
Yuan Cao1, Paulo Lizano2, Meng Li3
1Department of Nuclear Medicine, West China Hospital of Sichuan University, Chengdu 610041, China; Department of Psychiatry and Psychotherapy, Jena University Hospital, Jena 07743, Germany; Center for Intervention and Research on Adaptive and Maladaptive Brain Circuits Underlying Mental Health (C-I-R-C), Halle-Jena-Magdeburg, Germany; Clinical Affective Neuroimaging Laboratory (CANLAB), Leipziger Str. 44, Building 65, 39120 Magdeburg, Germany; Department of Radiology, Huaxi MR Research Center (HMRRC), Institute of Radiology, Functional and Molecular Imaging Key Laboratory of Sichuan Province, West China Hospital of Sichuan University, Chengdu, Sichuan, China.
免疫和代谢因素会影响双极二型抑郁症的脑结构. 较高的BMI和炎症与白质完整性的改变有关,特别是在体中,这表明有机械联系.
科学领域:
- 神经成像是一种神经成像.
- 精神病学是一个精神病学.
- 免疫学 免疫学 免疫学
- 代谢障碍 代谢障碍 代谢障碍
背景情况:
- 免疫代谢失调越来越多地与情绪障碍有关.
- 了解非侵入性大脑相关性对于将病理机制转化为临床实践至关重要.
研究的目的:
- 为了研究周围炎症,身体质量指数 (BMI) 和双极II型抑郁症 (BDII-D) 白质 (WM) 微观结构之间的相互关系.
- 探索这些因素对大脑中自由水 (FW) 和分数异构性 (FAt) 的影响.
主要方法:
- 用FSL Randomise对146名BDII-D患者和151名健康对照 (HC) 的FW和FAt进行了Voxel-wise分析.
- 部分相关性和适度分析,以评估BMI,炎症,WM措施和精神症状之间的关联.
主要成果:
- 与HC相比,BDII-D患者在体 (CC) 和双边前面冠状辐射体的基因中表现出较低的FAt,并在CC体中表现出较高的FW.
- 较高的BMI与较低的全球FAt相关,而较高的外周炎症与BDII-D中较高的全球FW相关.
- 较低的FAt (genu CC) 和较高的FW (body CC) 与增加的BMI,炎症和抑郁症状有关. 轻度炎症缓和了BMI-Fat的关系.
结论:
- 证据支持在BDII-D.中免疫代谢失调和改变的大脑连接之间存在机械联系.
- 周围炎症可能会调解BMI对白质完整性的影响,在炎症,BMI和基于MRI的特定通路标记物之间观察到明显的关系.
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