Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

T Cell Types and Functions01:24

T Cell Types and Functions

643
When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
643
The JAK-STAT Signaling Pathway01:20

The JAK-STAT Signaling Pathway

8.5K
Several cytokine receptors have tightly bound Janus kinase or JAK proteins attached at their cytosolic tail. Small signaling molecules such as cytokines, growth hormones, or prolactins bind to the cytokine receptors and initiate their dimerization. The dimerization brings the cytosolic JAKs together that trans-phosphorylate and activates each other. The activated JAKs now phosphorylate cytosolic tails of the cytokine receptors, which serve as binding sites for adaptor proteins such as  SH2...
8.5K
Autoimmune Disorders01:29

Autoimmune Disorders

328
Autoimmune diseases are a group of disorders in which the body's immune system mistakenly attacks its own cells, tissues, and organs. This results from an overactive immune response against substances and tissues normally present in the body. Let's delve into the concept and mechanism of autoimmune diseases from an immune system point of view, explore different causes and examples of such diseases, and discuss potential solutions.
Concept and Mechanism of Autoimmune Diseases
The immune...
328
Rh Blood Group01:19

Rh Blood Group

1.2K
The Rhesus (Rh) antigen is crucial in determining blood groups and ensuring compatibility during blood transfusions.
1.2K

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

[Risk of incident malignancies following exposure to Janus kinase inhibitors and biological DMARDs : An analysis from the RABBIT registry].

Zeitschrift fur Rheumatologie·2025
Same author

Real-world experience with filgotinib for rheumatoid arthritis in Germany : A retrospective chart review.

Zeitschrift fur Rheumatologie·2024
Same author

[Rheumatoid arthritis: Appraisement of the new security warnings for JAK-inhibitors].

Deutsche medizinische Wochenschrift (1946)·2024
Same author

[The progress in dermatomyositis (ProDerm) study : First phase III study on the use of intravenous immunoglobulins in dermatomyositis].

Zeitschrift fur Rheumatologie·2023
Same author

Hypochromic red cells as a prognostic indicator of survival among patients with systemic sclerosis screened for pulmonary hypertension.

Arthritis research & therapy·2023
Same author

Real-world treatment persistence in patients with rheumatoid arthritis initiating DMARDs in Germany-a health insurance claims data analysis.

Zeitschrift fur Rheumatologie·2023
Same journal

Deutsche medizinische Wochenschrift (1946)·2026
Same journal

["Not everything that looks like a tumor..." - Pulmonary tularemia with hilar lymphadenopathy].

Deutsche medizinische Wochenschrift (1946)·2026
Same journal

[Emergency management of sickle cell disease].

Deutsche medizinische Wochenschrift (1946)·2026
Same journal

[Hereditary dehydrated stomatocytosis (= hereditary xerocytosis) - Interesting hummingbird or clinically relevant diagnosis?]

Deutsche medizinische Wochenschrift (1946)·2026
Same journal

[Diagnosis of Congenital Hemolytic Anemias in Adults].

Deutsche medizinische Wochenschrift (1946)·2026
Same journal

[46-year-old female patient with right upper abdominal pain].

Deutsche medizinische Wochenschrift (1946)·2026
查看所有相关文章

相关实验视频

Updated: May 15, 2025

Author Spotlight: Implementation of BIVA for Analyzing Disease Risk Factors in Patients with Low Body Cell Mass
07:44

Author Spotlight: Implementation of BIVA for Analyzing Disease Risk Factors in Patients with Low Body Cell Mass

Published on: July 14, 2023

1.0K

[类风湿性关节炎] 这是什么?

Jutta Bauhammer, Christoph Fiehn

    Deutsche medizinische Wochenschrift (1946)
    |April 8, 2025
    PubMed
    概括
    此摘要是机器生成的。

    类风湿性关节炎 (RA) 是一种炎症性疾病,影响关节和潜在的肺部. 早期使用疾病修饰性抗风湿性药物 (DMARDs) 治疗,如甲状腺素,对于管理RA进展和改善患者的治疗结果至关重要.

    更多相关视频

    Author Spotlight: Enhancing Rheumatoid Arthritis Research Through HR-pQCT Imaging Analysis
    06:31

    Author Spotlight: Enhancing Rheumatoid Arthritis Research Through HR-pQCT Imaging Analysis

    Published on: October 6, 2023

    2.0K
    Author Spotlight: Isolation and Culture of Primary Synovial Macrophages and Fibroblasts from Murine Arthritis Tissue
    09:18

    Author Spotlight: Isolation and Culture of Primary Synovial Macrophages and Fibroblasts from Murine Arthritis Tissue

    Published on: February 24, 2023

    7.0K

    相关实验视频

    Last Updated: May 15, 2025

    Author Spotlight: Implementation of BIVA for Analyzing Disease Risk Factors in Patients with Low Body Cell Mass
    07:44

    Author Spotlight: Implementation of BIVA for Analyzing Disease Risk Factors in Patients with Low Body Cell Mass

    Published on: July 14, 2023

    1.0K
    Author Spotlight: Enhancing Rheumatoid Arthritis Research Through HR-pQCT Imaging Analysis
    06:31

    Author Spotlight: Enhancing Rheumatoid Arthritis Research Through HR-pQCT Imaging Analysis

    Published on: October 6, 2023

    2.0K
    Author Spotlight: Isolation and Culture of Primary Synovial Macrophages and Fibroblasts from Murine Arthritis Tissue
    09:18

    Author Spotlight: Isolation and Culture of Primary Synovial Macrophages and Fibroblasts from Murine Arthritis Tissue

    Published on: February 24, 2023

    7.0K

    科学领域:

    • 类风湿病学 类风湿病学
    • 免疫学 免疫学 免疫学
    • 内部医学 内部医学

    背景情况:

    • 类风湿性关节炎 (RA) 是一种全身性炎症性自身免疫性疾病,主要影响关节.
    • 它可以导致关节外的表现,如间歇性肺病和血管炎.
    • 未经治疗的RA会导致不可逆转的功能损失和死亡率的增加.

    研究的目的:

    • 概述了类风湿性关节炎的推治疗策略.
    • 强调早期诊断和有针对性的治疗的重要性.
    • 描述治疗到目标的原则来管理RA.

    主要方法:

    • 在诊断时给予疾病修饰性抗风湿药物 (DMARDs),其中甲状腺素作为首选.
    • 暂时使用葡萄糖皮质类药物3-6个月.
    • 使用治疗到点的方法,定期评估疾病活性得分.

    主要成果:

    • 治疗反应的定义是疾病活性得分至少减少50%,在12周和24周评估.
    • 如果治疗目标没有达到,就会进行调整,包括转向其他常规系统性 (cs) DMARDs,生物 (b) DMARDs,或有针对性的合成 (ts) DMARDs.
    • 连续的重新评估指导进一步的治疗调整.

    结论:

    • 早期和有针对性的治疗对于治疗类风湿性关节炎至关重要.
    • 以验证得分为指导的治疗到目标策略优化了治疗结果.
    • 个性化治疗调整是必要的,以实现缓解和预防疾病的进展.