在多中心艾滋病队列研究中的冠状动脉和全因死亡率
Takahiro Suzuki1, Sabina Haberlen2, Tess E Peterson3
1Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, United States; Department of Cardiovascular Medicine, St. Luke's International Hospital, Tokyo, Japan.
Atherosclerosis
|April 8, 2025
概括
冠状动脉 (CAC) 与艾滋病毒感染男性 (MWH) 的死亡率较高有关. 这种关联在整体队列中观察到,包括艾滋病毒感染和没有艾滋病毒感染的男性,突出显示CAC是显著的风险因素.
科学领域:
- 心脏病学 心脏病学
- 传染性疾病 传染性疾病
- 流行病学 流行病学
背景情况:
- 艾滋病毒感染者 (PWH) 面临患上亚临床心血管疾病的风险较高.
- 有限的研究存在于冠状动脉 (CAC) 和死亡率之间的关联,特别是在PWH.
研究的目的:
- 调查CAC与艾滋病毒感染者 (MWH) 和没有艾滋病毒感染者 (MWOH) 的男性全因死亡率之间的关系.
- 为了确定这种关联是否基于HIV血清状况而有所不同.
主要方法:
- 从多中心艾滋病队列研究数据的纵向分析.
- 包括接受非对比心脏计算机断层扫描的男性.
- 考克斯回归分析评估CAC存在/范围和死亡率之间的关联,评估HIV血清状况的差异,使用相互作用术语.
主要成果:
- CAC存在与MWH (aHR: 1.62) 和整体队列 (aHR: 1.46) 的死亡率有显著的相关性.
- CAC的程度还与MWH (aHR:1.41 per SD) 和整体队列 (aHR:1.37 per SD) 的死亡率相关.
- 在MWOH中没有发现CAC和死亡率之间的显著关联,也没有艾滋病毒血清状况的显著相互作用.
结论:
- 冠状动脉与艾滋病毒感染者的全因死亡率有关.
- CAC的存在和程度与MWH和联合队列的死亡风险增加有关.
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