剩余胆固醇和动脉硬之间的关联:来自NHANES 1999-2018年的证据
Tianjie Lai1, Yiyin Liang2, Fenglei Guan3
1Department of Spine Surgery, The Affiliated Yuebei People's Hospital of Shantou University Medical College, Shaoguan, Guangdong, 512000, China.
概括
较高的残留胆固醇 (RC) 与动脉硬度增加有关,这是心血管风险标志物. 这种关联显示出和效应,并且部分是由炎症介导的,特别是在年轻,女性和非西班牙裔白人个体中.
科学领域:
- 心血管疾病研究研究
- 脂质代谢 脂质代谢是什么
- 动脉生理学 动脉生理学
背景情况:
- 剩余胆固醇 (RC) 是一个新兴的心血管风险因素.
- RC和动脉硬之间的关系尚未完全理解.
- 通过估计脉冲波速度 (ePWV) 测量的动脉硬是心血管风险的关键指标.
研究的目的:
- 调查残留胆固醇 (RC) 水平与动脉硬度 (ePWV) 之间的关联.
- 加强对RC在动脉样硬化心血管疾病 (ASCVD) 风险评估中的作用的理解.
- 探索RC与动脉硬度关系中的潜在调解因素和人口差异.
主要方法:
- 利用了来自12505名成年人的国家健康和营养检查调查 (NHANES) 数据 (1999-2018).
- 采用加权线性回归,限制立方线 (RCS) 和子组分析.
- 使用炎症标志物 (NEU,NLR,MLR) 进行中介分析.
主要成果:
- 在较高的RC水平和升高的ePWV之间发现了显著的积极关联.
- RCS分析显示,在较高RC度下,与和效应存在非线性关系.
- 在年轻人 (<40岁),女性,非西班牙裔白人和贫困线以上的人群中观察到更强烈的关联.
- 炎症标志物 (NEU,NLR,MLR) 部分介导了RC和ePWV之间的关联.
结论:
- 升高的残留胆固醇与动脉硬度增加有关,表现出和效应.
- 这种关联部分由炎症标志物介导,包括中性粒细胞计数,NLR和MLR.
- 这种关系在特定的人口群体中更为明显:年轻人,女性,非西班牙裔白人以及不生活在贫困线以下的人.
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