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初潮时的年龄,2型糖尿病和心力衰竭:孟德尔的随机化研究
Jiayu Cheng1, Hengchi Yu1, Zimo Pan2
1Department of Endocrinology, Beijing Friendship Hospital, Capital Medical University, Beijing, 100050, China.
概括
晚期初潮 (AAM) 的晚年因果性降低了2型糖尿病 (T2DM),HbA1c水平和心力衰竭 (HF) 的风险. 这一发现支持AAM作为心血管和代谢疾病预防策略的一个因素.
科学领域:
- 生殖健康 生殖健康
- 代谢性疾病是一种代谢性疾病.
- 心血管疾病的心血管疾病.
背景情况:
- 观察性研究表明,初潮早期与2型糖尿病 (T2DM) 和心力衰竭 (HF) 风险增加之间存在联系.
- 这些关联的因果关系性质仍然不确定.
- 初潮时的年龄 (AAM) 是一个潜在的早期生命标志物,用于以后的健康结果.
研究的目的:
- 调查初潮时的年龄 (AAM) 和T2DM,HbA1c水平和HF之间的因果关系.
- 使用门德尔随机化 (MR) 来评估这些遗传因果关系.
主要方法:
- 使用大规模的全基因组关联研究 (GWAS) 总结统计数据进行了双样本的门德尔随机化 (MR) 分析.
- 仪器变量 (IV) 来自与AAM相关的全基因组显著单核酸多态 (SNP).
- 逆方差加权 (IVW) 方法是主要的分析方法,进行灵敏度分析以确保稳定性.
主要成果:
- 遗传预测后来的AAM与T2DM风险降低有关 (OR,0.881;P=6.92×10−7).
- 后来的AAM也与较低的HbA1c水平 (OR,0.964;P=2.06×10−5) 和降低HF风险 (OR,0.907;P=7.98×10−6) 有关.
- 这些因果关系甚至在排除与身体质量指数 (BMI) 相关的SNP之后仍然存在.
结论:
- 这项MR研究提供了强有力的证据,证明AAM对T2DM,HbA1c和HF的因果关系.
- 定期评估AAM可能有助于对这些疾病的临床风险分层.
- 这些发现支持基于AAM的有针对性的预防策略的制定.
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