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[在抗VEGF治疗下,中央血清性胆色素变异中,二次性黄斑新血管化的形态和功能变化]

Nikolai Kleefeldt¹, Sophia Kuehnel¹, Lukas Reiser¹

¹Augenklinik Würzburg, University Hospital Würzburg, Joseph-Schneider-Str. 11, 97080, Würzburg, Deutschland.

Die Ophthalmologie

|April 8, 2025

概括

光学连贯断层扫描血管造影 (OCT-A) 可靠地检测到中央血清性胆色素变异 (CCS) 中的二次黄斑新血管化 (sMNV). 海外国家和地区A确定了两种sMNV类型,但用抗血管内皮生长因子 (VEGF) 治疗在一年内没有显著减少sMNV大小.

科学领域:

眼科医生眼科眼科
医疗成像医学成像
视网膜疾病视网膜疾病

背景情况:

中央血清性胆色素病变 (CCS) 可能导致二次性黄斑新血管化 (sMNV).
了解治疗期间的sMNV形态和视力敏度变化至关重要.
抗血管内皮生长因子 (VEGF) 治疗是对sMNV的潜在治疗方法.

研究的目的:

用光学相干断层扫描血管学 (OCT-A) 来调查sMNV的形态变化.
在抗VEGF治疗期间评估sMNV患者的视力敏度的发展.
为了比较OCT-A和光素血管造影 (FA) 在检测sMNV的有效性.

主要方法:

在CCS中对sMNV的治疗先眼睛进行了回顾性研究.
患者通过预先预测 (PRN) 方案接受了抗VEGF治疗.
随访持续时间为1年,通过FA和OCT-A进行成像.

主要成果:

在100%的病例中,OCT-A检测到sMNV,相比之下,FA的病例为35%.
确定了两个不同的sMNV形态:"海风扇"和丝状.
在治疗1年后 (p=0.12),没有观察到smnv区域的统计学显著下降.

结论:

在检测CCS中的sMNV方面,OCT-A优于FA.
两种不同的形态类型的sMNV ("海风扇"和有线) 被OCT-A.确定.
在CCS中用静脉内注射 (IVOM) 治疗sMNV需要在第一年内与新血管年龄相关黄斑变性相似的数量.

关键词:

抗血管内皮生长因子抗血管内皮生长因子中央血清性胆色素变异症光素血管学光素血管学光学连贯性断层扫描血管图谱二次性黄斑新血管化

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