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Updated: May 15, 2025

Studying RNA Interactors of Protein Kinase RNA-Activated during the Mammalian Cell Cycle
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Published on: March 5, 2019

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在没有隔离的情况下,PACT可以防止内源dRNA对PKR的异常激活

Sadeem Ahmad1,2, Tao Zou3,4, Jihee Hwang2,5

  • 1Howard Hughes Medical Institute and Program in Cellular and Molecular Medicine, Boston Children's Hospital, Boston, MA, USA.

Nature communications
|April 8, 2025
PubMed
概括

蛋白质PACT抑制了细胞dRNA的双链RNA (dsRNA) 传感器PKR激活. PACT阻止了沿着dsRNA进行PKR扫描,微调免疫反应并预防疾病.

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