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Updated: May 15, 2025

A Mouse Model to Investigate the Role of Cancer-Associated Fibroblasts in Tumor Growth
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A Mouse Model to Investigate the Role of Cancer-Associated Fibroblasts in Tumor Growth

Published on: December 22, 2020

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仅CXCL12就足以将正常纤维细胞重新编程成与癌症相关的纤维细胞

Zelong Ma1, Diping Yu2, Siqi Tan1

  • 1Laboratory of Molecular Genetics of Aging & Tumor, Medical School, Kunming University of Science and Technology, Chenggong Campus, 727 South Jingming Road, Kunming, Yunnan, 650500, China.

Cell death discovery
|April 8, 2025
PubMed
概括

癌症相关纤维细胞 (CAF) 在肺癌中通过CXCL12/STAT3通路驱动正常的纤维细胞转化. 抑制这个轴阻碍瘤生长和转移,提供了一个潜在的治疗策略.

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Experimental Generation of Carcinoma-Associated Fibroblasts CAFs from Human Mammary Fibroblasts

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Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...
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