信息处理速度对复发性复发性和初级渐进性多发性硬化症患者的记忆过程的影响
Carolin Balloff1,2,3,4, Sven G Meuth5, Heinz Wiendl6
1Department of Neurology, Medical Faculty and University Hospital Düsseldorf, Heinrich Heine University, Moorenstrasse 5, 40225, Düsseldorf, Germany. carolin.balloff@med.uni-duesseldorf.de.
Scientific reports
|April 8, 2025
概括
信息处理速度 (IPS) 是多发性硬化症 (MS) 中的一个核心认知缺陷. 损坏的IPS显著影响MS (pwMS) 患者的口头学习和记忆,特别是在初级进展性MS (PPMS) 与复发性复发性MS (RRMS) 相比.
科学领域:
- 神经科学是一个神经科学.
- 认知心理学 认知心理学
- 临床神经学 临床神经学
背景情况:
- 信息处理速度减慢 (IPS) 是患有多发性硬化症 (pwMS) 的人的主要认知障碍.
- 不同多发性硬化症 (MS) 现型中IPS,口头学习 (VL) 和口头记忆 (VM) 之间的特定关系尚未完全理解.
- 了解这些认知领域的关系对于管理MS相关认知功能障碍至关重要.
研究的目的:
- 在早期复发性复发性多发性硬化 (pwRRMS),初级进展性多发性硬化 (pwPPMS) 和健康对照 (HC) 中调查IPS,VL和VM.
- 检查不同MS表型中的IPS,VL和VM之间的关系.
- 确定核心认知缺陷及其对MS其他认知功能的影响.
主要方法:
- 这是一项双中心研究,涉及92个 pwMS (61个 pwRRMS,31个 pwPPMS) 和61个年龄相匹配的HC.
- 在所有参与者中对IPS,VL和VM的详细评估.
- 回归分析以确定认知领域之间的预测关系.
主要成果:
- 在所有认知指标上,PwPPMS的表现明显低于HC;在IPS和VL上,pwRRMS的表现低于HC.
- IPS损伤是核心赤字,影响了25%的 pwRRMS 和45%的 pwPPMS.
- 在两组MS中,IPS显著预测了VL和VM的表现,pwPPMS在IPS和VL中显示出比pwRRMS更明显的赤字.
结论:
- IPS损伤是MS中普遍存在的认知缺陷,在现象类型中显著影响口头学习和记忆.
- 与 pwRRMS 相比,PwPPMS 经历了更严重的认知变化,特别是在 IPS 和 VL 中,与 pwRRMS 相比.
- 针对IPS的干预措施对于管理MS患者的认知功能障碍至关重要.
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