微生物组-代谢组动态与血糖控制受损和对生活方式变化的反应相关
Hao Wu1, Bomin Lv2, Luqian Zhi2
1Center for Obesity and Hernia Surgery, Department of General Surgery, Huashan Hospital, and State Key Laboratory of Genetic Engineering, Fudan Microbiome Center, Human Phenome Institute, Fudan University, Shanghai, China. hao_w@fudan.edu.cn.
Nature medicine
|April 8, 2025
概括
2型糖尿病 (T2D) 涉及肠道微生物组的变化,影响血液代谢物和葡萄糖控制. 生活方式干预可以修改这些微生物组-代谢组相互作用,以更好地管理T2D.
科学领域:
- 代谢学 代谢学 代谢学
- 微生物组研究 微生物组研究
- 内分泌学 在内分泌学.
背景情况:
- 2型糖尿病 (T2D) 是一种复杂的代谢障碍,受遗传和环境因素的影响.
- 最近的研究强调了病理生理异质性和T2D和糖尿病前期的不同亚组.
- 个性化的风险因素识别对于有效的T2D管理至关重要.
研究的目的:
- 为了研究血液代谢物,肠道微生物组变化和瑞典队列中葡萄糖控制受损之间的关联.
- 探索微生物组-代谢轴在调节葡萄糖平衡中的作用.
- 评估生活方式改变对微生物组相关代谢物的影响.
主要方法:
- 在两个瑞典队列 (n=1,167) 中利用代谢学来识别与血糖控制相关的血液代谢物.
- 分析了已识别的代谢物和肠道微生物组合之间的关系.
- 研究了短期生活方式变化 (饮食,运动) 对代谢物概况的影响.
主要成果:
- 识别了500多种与血糖控制受损相关的血液代谢物.
- 大约三分之一的这些代谢物与改变的肠道微生物组有关.
- 通过hippurate证明了特定细菌 (Hominifimenecus microfluidus,Blautia wexlerae) 之间的潜在相互作用,影响葡萄糖平衡.
- 观察到微生物组相关代谢物的特定生活方式调节.
结论:
- 微生物组-代谢组轴内的代谢干扰是T2D中危害葡萄糖平衡的潜在媒介.
- 微生物组-代谢组轴代表了T2D的可修改的治疗目标.
- 结合生活方式的修改为T2D管理提供了最佳的健康益处.
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