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斯芬哥辛激酶2的缺陷通过抑制mTORC2酸化和激活伴侣介导的自酶来损害VLDL分泌

Shuangshuang Zhang1, Gaoxiang Li1, Lianping He2

  • 1School of Life Sciences, Anhui Medical University, Hefei, 230032, Anhui, China.

Cell death and differentiation
|April 8, 2025
PubMed
概括

斯芬哥辛激酶2 (SphK2) 缺乏会通过加快SNARE蛋白降解,通过伴侣介导的自,损害极低密度脂蛋白 (VLDL) 的分泌. 激活mTORC2或补充S1P可以恢复VLDL分泌,提供潜在的MASLD治疗方法.

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