三级淋巴体结构与在性黑色素瘤中改善生存率和增强抗瘤免疫力有关
Xinyu Su1, Donglin Kang2, Jiayu Wang3
1Department of the Comprehensive Cancer Center, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, China.
NPJ precision oncology
|April 8, 2025
概括
在状黑色素瘤 (AM) 病变中,三级淋巴体结构 (TLS) 与更好的生存率有关. 它们的存在表明T细胞透率增加,并预测免疫治疗的积极反应.
科学领域:
- 在瘤学瘤学.
- 免疫学 免疫学 免疫学
- 皮肤病学 皮肤病学
背景情况:
- 三级淋巴体结构 (TLS) 在瘤内的免疫反应中发挥作用.
- 了解TLS对状黑色素瘤 (AM) 和其瘤微环境 (TME) 的影响,对于治疗策略至关重要.
研究的目的:
- 为了研究TLS在原发性状黑色素瘤的预后意义.
- 分析瘤内部TLS和瘤微环境特征之间的关联.
- 评估TLS相关基因特征在预测患者存活率和免疫治疗反应方面的潜力.
主要方法:
- 从46名患者的初级状黑色素瘤病变中分析TLS特征.
- 血素和氨酸染色和多重免疫光学用于TME的特征.
- 转录组分析以确定与TLS相关的基因组.
主要成果:
- 在25名患者中发现了内TLS (内TLS),与改善的整体存活率显著相关.
- 患有内TLS的患者显示T细胞和CD8+T细胞透率增加,TME中瘤相关的巨细胞减少.
- 与TLS相关的Th1/B细胞基因组成为生存和免疫治疗反应的预测因素.
结论:
- 内TLS在状黑色素瘤中具有显著的预后价值.
- TLSs的存在影响瘤微环境的组成,有利于抗瘤免疫力.
- 准TLS形成是一个潜在的策略,以提高免疫疗法在状黑色素瘤患者的疗效.
相关概念视频
01:27Tumor Immunotherapy
411
Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
411
02:17The Tumor Microenvironment
6.5K
Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...
6.5K
01:30Skin Cancer
3.0K
Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
3.0K
01:15Secondary Lymphoid Organs
825
Secondary organs, including lymph nodes, the spleen, and mucosa-associated lymphoid tissue (MALT), work harmoniously to protect us from disease and infection.
The spleen is a vital organ in the lymphatic system, nestled in the upper left side of the abdomen. It is composed of two primary regions: the red pulp and the white pulp, each having distinct functions. The red pulp performs a significant role in blood filtration. It efficiently purges the blood of old or damaged red blood cells and...
The spleen is a vital organ in the lymphatic system, nestled in the upper left side of the abdomen. It is composed of two primary regions: the red pulp and the white pulp, each having distinct functions. The red pulp performs a significant role in blood filtration. It efficiently purges the blood of old or damaged red blood cells and...
825