高灵敏度的C-反应蛋白涉及异质的代谢表型和严重程度的代谢功能障碍与稳态性肝病相关
Hao Wang1,2, Junzhao Ye1, Youpeng Chen2
1Department of Gastroenterology, The First Affiliated Hospital, Sun Yat-Sen University, Yuexiu District, No. 58 Zhongshan II Road, Guangzhou, 510080, China.
BMC gastroenterology
|April 8, 2025
概括
高灵敏度C反应蛋白 (Hs-CRP) 与代谢功能障碍相关的脂肪性肝病 (MASLD) 患者的肝脂肪和硬度相关. 然而,它对疾病进展的预测能力仍然有限.
科学领域:
- 肝病学 肝病学是一种肝病学.
- 生物标志物 生物标志物
- 炎症 炎症是一种炎症.
背景情况:
- 与代谢功能障碍相关的脂肪性肝病 (MASLD) 的发展与全身炎症有关.
- 高灵敏度C反应蛋白 (Hs-CRP) 在MASLD诊断中的作用正在调查中.
- 更新的MASLD定义需要重新评估炎症标志物.
研究的目的:
- 评估Hs-CRP的诊断价值与MASLD中的常规炎症标志物相比.
- 在MASLD患者中调查Hs-CRP与肝脂肪含量 (LFC) 和肝硬度测量 (LSM) 之间的关联.
- 评估Hs-CRP对代谢功能障碍相关的脂肪肝炎 (MASH) 和肝纤维化的预测性能.
主要方法:
- 一项涉及1006名超声诊断MASLD患者和582名健康对照者的横截面研究.
- 肝脏脂肪含量 (LFC) 量化使用MRI质子密度脂肪分数 (n=733).
- 通过2D剪波弹性成像评估肝硬度测量 (LSM);175名患者接受了肝活检.
主要成果:
- 在超重/肥胖的MASLD患者中,hs-CRP与LFC呈正相关性 (β=0.19,P=0.03).
- 在瘦肉/正常体重的MASLD患者中,HS-CRP与LSM相关 (β=0.30,P<0.001).
- Hs-CRP对MASH的预测能力较弱 (AUC=0.65-0.74在超重/肥胖和T2D组中).
结论:
- Hs-CRP水平与超重/肥胖MASLD中的LFC和瘦肉MASLD中的LSM有关.
- 对MASH和肝纤维化Hs-CRP的预测性能有限.
- 需要进一步的研究来确定HS-CRP在MASLD诊断和进展中的作用.
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