氧化平衡得分和肺功能与FeNO和美国人口死亡率之间的关联
Chang Liu1, Dan Liang2,3, Guoan Xiang4
1School of Medicine, Nankai University, Tianjin, China. 1471780945@qq.com.
BMC pulmonary medicine
|April 8, 2025
概括
较高的氧化平衡评分 (OBS) 与更好的肺功能 (FEV1,FVC,PEF) 和较低的全因死亡率有关. 富含抗氧化剂的饮食和健康的生活方式可以改善肺部健康并降低死亡风险.
科学领域:
- 环境健康 环境健康
- 营养流行病学 营养流行病学
- 肺部医学 肺部医学
背景情况:
- 氧化平衡得分 (OBS) 量化了整体氧化应激,较高的得分表明更大的抗氧化剂暴露.
- 关于OBS与肺功能或FeNO之间的关联存在有限的研究.
研究的目的:
- 研究OBS,生活方式OBS,饮食OBS和肺功能参数 (FEV1,FVC,PEF,FEF 25%-75%,FeNO) 之间的关系.
- 探索OBS与全因和呼吸相关死亡率之间的关联.
主要方法:
- 使用了来自8,568名参与者的NHANES数据 (2007-2012).
- 采用多变量逻辑回归和受限立方支线 (RCS) 分析来评估OBS与肺功能/死亡之间的关联.
- 进行了子组分析和相互作用测试.
主要成果:
- 在OBS,生活方式OBS,饮食OBS和肺功能参数 (FEV1,FVC,PEF) 之间发现了显著的积极关联.
- 在OBS和FeNO水平之间没有观察到任何关联.
- 较高的OBS和饮食OBS与较低的全因死亡率有关,而生活方式OBS与较低的呼吸相关死亡率有关.
结论:
- 在美国成年人中,OBS,生活方式OBS和饮食OBS与肺功能有积极的相关性.
- 较高的OBS与所有原因死亡率的降低有关.
- 促进健康的生活方式和富含抗氧化剂的饮食可以减轻氧化应激,改善肺部健康结果.
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