在超重或肥胖的青少年中补充基托桑后肠道微生物群的变化:一项随机,双盲临床试验
Somaye Fatahi1, Mohammad Hassan Sohouli2, Koroush Vahidshahi3
1Department of Clinical Nutrition and Dietetics, Faculty of Nutrition and Food Technology, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Diabetology & metabolic syndrome
|April 8, 2025
概括
在超重的青少年中,素补充剂显著降低了bmiz分数和改变了肠道细菌,增加了有益的bacteroidetes和akkermansia,同时降低了firmicutes. 需要进一步研究乳酸菌种群对乳酸菌的影响.
科学领域:
- 微生物学 微生物学
- 营养科学 营养科学
- 儿科内分泌学 儿科内分泌学
背景情况:
- 超重和肥胖与肠道微生物组失调有关.
- 纤维补充剂,如酸盐,显示出调节肥胖个体肠道微生物群的潜力.
- 基托桑对青少年肠道微生物群的具体影响仍在争论中.
研究的目的:
- 研究素补充剂对超重和肥胖青少年肠道微生物组合的影响.
- 为了确定基托桑是否会影响与肥胖相关的关键细菌种群.
主要方法:
- 一项为期12周的随机对照试验,涉及64名超重/肥胖青少年.
- 素 (3g/天) 补充剂,测量人类指数和身体活动.
- 便样本的实时PCR分析,以量化细菌种群.
主要成果:
- 素显著降低了BMI z-分数 (P < 0.001).
- 素减少了Firmicutes (P < 0.001) 和增加了Bacteroidetes (P = 0.008) 和Akkermansia (P < 0.001) 种群.
- 固菌菌/细菌菌的比率显著下降 (P < 0.001);乳酸菌变化略显 (P = 0.05),而双菌保持不变 (P = 0.97).
结论:
- 在超重/肥胖的青少年中,基托桑对特定肠道细菌物种产生有益影响.
- 这项研究强调了酸盐有潜力调节肠道微生物群,影响与肥胖相关的细菌.
- 需要进一步的研究来证实这些发现,并阐明对乳杆菌种群的影响.
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