在患有幼年系统性红斑狼和发烧的患者中发生细菌感染
José Fernando Gómez-Urrego1,2,3,4, Nathalie Yepes-Madrid5,6,7, Mónica Alexandra Gil-Artunduaga5,6,7
1Universidad Libre Seccional Cali, Cali, Valle del Cauca, Colombia. josef.gomezu@unilibre.edu.co.
Pediatric rheumatology online journal
|April 8, 2025
概括
青少年系统性红斑狼 (JSLE) 患者的发烧可以表明细菌感染. 高于0.9 ng/mL的前素 (PCT) 是一个关键指标,有助于早期诊断和管理JSLE感染.
科学领域:
- 儿科 儿科 儿科
- 类风湿病学 类风湿病学
- 传染性疾病 传染性疾病
背景情况:
- 青少年系统性红斑狼 (JSLE) 是一种慢性自身免疫性疾病,增加了感染风险.
- 患有JSLE患者的发烧可能源于感染,狼活动或两者兼而有之.
- 在JSLE中区分感染与疾病爆发仍然具有挑战性.
研究的目的:
- 为了确定与发烧性JSLE患者的细菌感染相关的临床和生物标记因子.
- 评估各种标志物的实用性,以区分细菌感染与其他引起JSLE发烧的原因.
主要方法:
- 进行了一项病例控制研究.
- 评估的因素包括人口统计,药物使用和实验室标记,如ESR,CRP,费里丁,NLR,PLR,PCT,LC4R和ESR/CRP比率.
- 进行了统计分析,以确定细菌感染的重要预测因素.
主要成果:
- 在116名JSLE患者中,17%的患者存在细菌感染.
- 在调整后的模型中,前素 (PCT) > 0.9 ng/mL 是细菌感染的显著预测因子 (p < 0.01).
- 其他标记物如NLR,PLR,ESR/CRP比率,LC4R和费里丁显示出潜力,但需要进一步验证.
结论:
- 甲 > 0.9 ng/mL 是在发烧性JSLE患者中识别细菌感染的关键标记.
- 需要进一步的研究来确定其他研究的标记物的最终切断值.
- 对于准确的诊断,个别患者的评估仍然是必不可少的.
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