长期COVID患者的临床表型在一个专门的神经COVID诊所进行评估
Luana D Yamashita1, Neel Desai2, Abigail R Manning1
1Department of Neurology, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Annals of clinical and translational neurology
|April 9, 2025
概括
长期COVID患者经常报告认知症状和神经问题,如头痛和头. 大多数患者在一年内自我报告的改善,尽管认知测试得分并不总是与报告的症状一致.
科学领域:
- 神经学 神经学
- 传染性疾病 传染性疾病
- 认知科学 认知科学
背景情况:
- 长期COVID是SARS-CoV-2感染后的疾病,呈现出多样化和持久的症状.
- 神经和认知障碍是长期COVID患者的重大问题.
- 了解长期COVID的特征和恢复轨迹对于患者管理至关重要.
研究的目的:
- 在专门诊所评估的患者中描述长期COVID症状和神经学发现.
- 分析神经和认知疾病的纵向过程和恢复模式.
- 评估与患者报告的症状相关的神经认知查测试的表现.
主要方法:
- 在宾夕法尼亚大学神经COVID诊所 (PNCC) 评估的240名确诊SARS-CoV-2感染患者的回顾性研究.
- 包括182名患者的初始评估和纵向随访数据.
- 使用了标准化的神经学评估,包括蒙特利尔认知评估 (MoCA) 和口腔踪迹测试-B (OTMT-B).
主要成果:
- 常见的长期COVID投诉包括头痛 (60%),头/头 (40%) 和味觉/嗅觉障碍 (40%).
- 94%的患者报告了认知症状,超过30%的患者表现出异常的认知测试分数.
- 严重的急性感染,低学历和非白人种族与较差的认知测试表现有关;62%的人在一年内报告改善.
结论:
- 认知查测试的表现可能不完全反映长期COVID的认知投诉的程度.
- 自我报告的初级神经症状的改善是一个常见的临床轨迹在一年内.
- 需要进一步的研究来协调客观认知测试与长期COVID患者的主观体验.
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