在类风湿性关节炎中甲状腺疾病的谱
Megha S Kumar1, Shiji Pallivalappil2, Adarsh S Nair3
1Assistant Professor, Department of General Medicine, Sree Gokulam Medical College and Research Foundation, Thiruvananthapuram, Kerala, India, Corresponding Author.
The Journal of the Association of Physicians of India
|April 9, 2025
概括
甲状腺功能障碍影响38.2%的类风湿性关节炎 (RA) 患者,甲状腺功能低下是最常见的. 患有甲状腺问题的RA患者表现出更高的疾病活性,这强调了在RA护理中需要进行常规甲状腺查的必要性.
科学领域:
- 类风湿病学 类风湿病学
- 内分泌学 在内分泌学.
- 免疫学 免疫学 免疫学
背景情况:
- 类风湿性关节炎 (RA) 是一种慢性自身免疫性疾病,影响全球人口的0.5-1%.
- 由于共享的自身免疫病原发生,RA和甲状腺功能障碍的同时发生越来越被认可.
- 甲状腺疾病可以加剧RA疾病的活性,并对患者的生活质量产生负面影响.
研究的目的:
- 为了确定RA患者甲状腺功能障碍的患病率和类型.
- 为了比较甲状腺功能障碍和没有甲状腺功能障碍的RA患者之间的疾病活性水平.
- 调查RA严重程度与甲状腺功能障碍之间的关联.
主要方法:
- 进行了一项涉及165名RA患者的横截面研究.
- 测量了TSH,自由T4,自由T3和抗TPO抗体的血清水平.
- 分析了数据,以评估甲状腺疾病的患病率及其与RA疾病活动的关联.
主要成果:
- 甲状腺功能障碍存在于RA患者的38.2%,主要是亚临床甲状腺功能低下 (33.3%).
- 甲状腺功能障碍的RA患者表现出明显更高的疾病活性 (p=0.001) 和升高的炎症标志物.
- 在血清TSH,抗TPO抗体和疾病活动评分-28 (DAS-28) 之间发现了强烈的正相关性.
结论:
- 亚临床甲状腺功能低下症是RA患者中最常见的甲状腺疾病,影响38.2%.
- 甲状腺功能障碍与RA疾病活动和严重程度的增加显著相关.
- 建议对所有RA患者进行常规甲状腺功能测试,以确保及时诊断和治疗.
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