肺栓塞生存预测使用基于计算机断层扫描,血管学和临床数据的多式学习
Zhusi Zhong1,2,3, Helen Zhang1,2, Fayez H Fayad1,2
1Department of Diagnostic Radiology, Rhode Island Hospital.
Journal of thoracic imaging
|April 9, 2025
概括
集成计算机断层扫描肺血管造影 (CTPA) 成像,临床数据和PE严重性指数 (PESI) 的深度学习模型,与单独的PESI相比,可以更好地预测肺栓塞 (PE) 存活率. 这些模型有效地根据风险对患者进行分层,有助于预测生存结果.
科学领域:
- 肺部医学 肺部医学
- 人工智能的人工智能
- 医学成像分析 医学成像分析
背景情况:
- 肺栓塞 (PE) 是导致死亡的主要原因.
- 准确的生存预测对于管理PE患者至关重要.
- 当前的预测方法可能会从先进的分析工具中受益.
研究的目的:
- 开发和评估深度学习 (DL) 模型来预测PE生存率.
- 为了整合计算机断层扫描肺血管造影 (CTPA) 成像功能,临床数据和PE严重性指数 (PESI) 评分.
- 为了比较多式联运DL模型与传统方法的性能.
主要方法:
- 追溯分析了918名患有3978例CTPA的患者.
- 人工智能模型用于从CTPA中提取成像特征.
- 开发多式CoxPH模型,结合DL特征,临床数据和PESI分数.
- 使用一致性指数 (c指数) 和卡普兰-梅尔分析评估的性能.
主要成果:
- 结合CTPA特征,临床数据和PESI的多模式DL模型实现了比单独的PESI更高的c指数.
- 通过模型分层显著差异化了生存结果 (P<0.001).
- 在高风险组和右心室 (RV) 功能障碍之间观察到强烈的相关性.
结论:
- 综合CTPA,临床数据和PESI的多原子DL模型提供了卓越的PE生存预测.
- 这些先进的模型增强了风险分层,并可以为临床决策提供信息.
- DL模型在改善PE的预后准确性方面表现有前途.
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