在住院的SARS-CoV-2患者中,上部胃肠道出血的发生率和结果
Erin Sanzone1, Katherine Gheysens2, Krystal Hunter3
1Cooper Medical School of Rowan University, Camden, New Jersey, USA.
Gastroenterology research and practice
|April 9, 2025
概括
患有严重急性呼吸系统应急综合征冠状病毒2 (SARS-CoV-2) 的患者经历了更多的上胃肠道出血 (UGB) 和更高的死亡率. 与对照组相比,SARS-CoV-2阳性患者需要更多的输血和UGB干预.
科学领域:
- 胃肠病学 胃肠病学
- 传染性疾病 传染性疾病
- 内部医学 内部医学
背景情况:
- 由于COVID-19的流行,人们对SARS-CoV-2患者的胃肠道 (GI) 出血产生了担忧.
- SARS-CoV-2 可以直接感染肠道上皮细胞,导致组织损伤.
- 在这些患者中使用抗凝剂进一步增加了胃肠道出血的风险.
研究的目的:
- 调查SARS-CoV-2阳性患者上部胃肠道出血 (UGB) 的发生率,特征和结果.
- 为了比较SARS-CoV-2阳性和阴性个体之间的UGB管理和死亡率.
- 了解SARS-CoV-2感染和肠道出血之间的关系.
主要方法:
- 一项对18岁以上的患者进行的回顾性研究,这些患者接受了UGB.
- 包括标准:阳性SARS-CoV-2测试,UGB和内镜检查.
- 收集的数据包括症状,药物,出血源和干预措施.
主要成果:
- 十二指肠是SARS-CoV-2阳性患者中UGB的主要原因;对照中的食道炎.
- SARS-CoV-2 患者出现了渐进性贫血,需要更多的输血,类固醇,PPI 和免疫抑制剂.
- 在SARS-CoV-2阳性患者 (12.8%) 与对照组 (5.1%) 的住院死亡率明显高.
- SARS-CoV-2 患者接受了更多的治疗干预;近25%的患者在出血开始后超过48小时内镜检查.
结论:
- 医疗保健提供者必须认识到,对UGB的SARS-CoV-2阳性患者的治疗需求增加.
- 研究结果强调了SARS-CoV-2感染,肠道组织损伤和随后的出血事件之间的联系.
- 这项研究为在COVID-19流行病背景下管理胃肠道出血提供了关键的见解.
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