在新辅助化疗期间脂肪组织损失:在晚期上皮卵巢卵巢癌的关键预后因素
Wassim Benouali1, Adeline Dolly2, Aurore Bleuzen1
1Radiology Department, Hôpital Bretonneau, CHRU de Tours, Tours, France.
Frontiers in physiology
|April 9, 2025
概括
化疗期间内脏脂肪组织的显著损失预示着晚期卵巢癌的生存率不佳. 针对减肥的早期干预措施可能会改善患者的治疗结果.
科学领域:
- 在瘤学瘤学.
- 放射学 放射学是一门学科.
- 身体组成分析 身体成分分析
背景情况:
- 先进的上皮卵巢癌 (EOC) 患者接受新辅助化疗 (NAC).
- 在NAC后的间隔手术是一个关键的预后因素.
- 在NAC期间的身体组成变化可能会影响患者的结果.
研究的目的:
- 分析NAC期间在高级EOC患者的身体组成变化 (肌肉和脂肪质量).
- 确定这些参数是否与无复发生存率 (RFS) 和总生存率 (OS) 相相关.
主要方法:
- CT成像分析了骨肌肉指数 (SMI),内脏脂肪组织指数 (VATI),皮下脂肪组织指数 (SATI),瘦体质量 (LBM) 和全身脂肪质量 (WFM).
- 身体组成的变化每100天正常化.
- 使用Log-rank测试进行的生存分析.
主要成果:
- 低SMI (肉症) 是常见的,但与生存无关.
- 在NAC期间观察到的VATI,SATI和估计WFM的显著下降.
- 快速失去VATI和WFM与较短的OS相关.
- 肥胖患者经历了更大的肌肉和脂肪损失.
结论:
- 在NAC期间早期和大量的内脏脂肪组织损失预测了晚期EOC的生存率不佳.
- 需要有针对性的营养或制药策略来缓解脂肪损失.
- 干预措施可以改善NAC.接受高级EOC患者的结果.
相关概念视频
02:07Tumor Progression
Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
01:12Loss of Tumor Suppressor Gene Functions
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When the tumor suppressor genes develop mutations or are lost, cells start growing out of control, leading to cancer. However, a single functional copy of the tumor suppressor gene is enough for the cells to maintain their normal functions and cell...
When the tumor suppressor genes develop mutations or are lost, cells start growing out of control, leading to cancer. However, a single functional copy of the tumor suppressor gene is enough for the cells to maintain their normal functions and cell...
02:07Tumor Progression
Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
01:12Loss of Tumor Suppressor Gene Functions
Tumor suppressor genes are normal genes that can slow down cell division, repair DNA mistakes, or program the cells for apoptosis in case of irreparable damage. Hence, they play an essential role in preventing the proliferation of damaged cells.
When the tumor suppressor genes develop mutations or are lost, cells start growing out of control, leading to cancer. However, a single functional copy of the tumor suppressor gene is enough for the cells to maintain their normal functions and cell...
When the tumor suppressor genes develop mutations or are lost, cells start growing out of control, leading to cancer. However, a single functional copy of the tumor suppressor gene is enough for the cells to maintain their normal functions and cell...