在患有阻塞性睡眠呼吸暂停的儿童中,认知功能障碍和尿中的8-OHdG水平之间的关系
Bolin Chen1, Jiapeng Ji1, Meng Lv1
1Department of Respiratory, Children's Hospital of Soochow University, Suzhou, China.
Frontiers in neurology
|April 9, 2025
概括
在患有阻塞性睡眠呼吸暂停 (OSA) 的儿童中,尿液中的8-基-2'-脱氧氨 (8-OHdG) 水平较高,与认知功能障碍相关. 这表明8-OHdG可能是一个有用的生物标志物,用于评估患有OSA的儿童的认知问题.
科学领域:
- 儿科睡眠医学 儿科睡眠医学
- 神经科学是一个神经科学.
- 生物化学 生物化学
背景情况:
- 儿童的阻塞性睡眠呼吸暂停 (OSA) 可能导致神经认知缺陷.
- 氧化应激与OSA相关的疾病有关.
- 8-基-2-脱氧氨酸 (8-OHdG) 是氧化DNA损伤的一个关键标记物.
研究的目的:
- 调查尿中8-OHdG水平与患有OSA儿童的认知功能障碍之间的关联.
- 确定8-OHdG是否可以作为儿科OSA认知障碍的生物标志物.
主要方法:
- 研究包括99名患有OSA的儿童和35名对照.
- 参与者接受了多睡眠学 (PSG),PedsQL问卷,并收集尿液进行8-OHdG分析.
- 测量了尿液中的8-OHdG水平,并与临床参数和认知得分相关联.
主要成果:
- 与非OSA对照组相比,患有OSA的儿童在尿液中表现出明显更高的8-OHdG水平 (p < 0.001).
- 8-OHdG水平与OSA严重程度相关 (例如,呼吸暂停-呼吸暂停指数,SaO2) 和认知功能障碍得分.
- 后勤回归显示,8-OHdG与学校运作得分有显著的相关性 (p = 0.004).
结论:
- 在患有OSA的儿童中,尿液中的8-OHdG水平升高.
- 8-OHdG水平与OSA严重程度和认知缺陷相关.
- 尿中的8-OHdG显示出作为儿童OSA认知功能障碍的非侵入性生物标志物的潜力.
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