根据不同时间点的炎症状况预测接受新辅助化疗的三阴性乳腺癌患者的预后:倾向性得分匹配分析
Qian Guo1, Bingping Wang1, Xinran Gao1
1Department of Breast Surgical Oncology, Inner Mongolia People's Hospital, Hohhot, Inner Mongolia Autonomous Region 010017, P.R. China.
Oncology letters
|April 9, 2025
概括
化疗前和手术前的炎症标志物,如系统性免疫炎症指数 (SII),预测三阴性乳腺癌 (TNBC) 患者接受新辅助治疗的整体存活率. 较高的炎症评分表明结果较差,突出显示了它们的预后价值.
科学领域:
- 在瘤学瘤学.
- 免疫学 免疫学 免疫学
背景情况:
- 三阴性乳腺癌 (TNBC) 是一种具有有限治疗选择的侵袭性亚型.
- 识别预后标志物对于改善TNBC患者的治疗结果至关重要.
研究的目的:
- 评估化疗前和手术前炎症状况对接受新辅助治疗的TNBC患者预后的预测能力.
- 评估TNBC中炎症标志物和整体存活率 (OS) 之间的关联.
主要方法:
- 对接受新辅助化疗的422名TNBC患者的分析.
- 评估炎症标志物:中性粒细胞与淋巴细胞的比率 (NLR),血小板与淋巴细胞的比率 (PLR),全身免疫炎症指数 (SII) 和全身炎症反应指数 (SIRI).
- 使用接收机运行特征曲线,生存分析和倾向得分匹配 (PSM).
主要成果:
- 化疗前和手术前高的NLR,PLR,SII和SIRI得分与较短的OS相关 (P<0.05).
- 多变量分析确定了瘤结节转移阶段,病理完整反应和手术前SII作为OS的独立预后因素.
- 在PSM分析中,证实高SII分数与较短的OS相关 (P=0.004).
结论:
- 化疗前和手术前的炎症状态都与接受新辅助化疗的TNBC患者的OS有关.
- 手术前的SII在这个队列中成为总体生存的重要独立预后因素.
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